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Astragalus: Benefits, Reviews, Warnings?

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Astragalus: Benefits, Reviews, Warnings?
(Astragalus membranaceus)

Pharmacological studies of astragalus root were mainly carried out with aqueous extracts or fractions enriched in saponins and polysaccharides. Are described hepatoprotective properties, antioxidants, immunostimulants, antiviral.

Astragalus root has immunostimulatory properties, but unlike Echinacea, does not suppress immune function with prolonged use. Activity is related to its content of polysaccharides, and the sugar moiety that stimulates NK cells, enhance the functions of T cells and increase the production of interferon.
The root of Astragalus administration improves peripheral tissue oxygenation and the stress response by adrenal activity increase. The pharmacological response was related to the presence of triterpene saponins and since this fraction is responsible for the increase of the adrenal activity.
The root of Astragalus also has radioprotective properties.

1 -. Hepatoprotective properties. Extract Astragalus root protects the liver from damage by CCl4, prevents the decrease of liver glycogen, and increases the level of serum protein and albumin. Were clinical studies with extracts of Astragalus. In 1 to 2 months the symptoms of the disease decrease, improves the welfare state and the patient's appetite and GPT levels return to normal. In patients with chronic hepatitis treated with Astragalus improves cellular immunity and phagocytosis of reticuloendothelial cells is stimulated.

2 -. Inflammatory properties. Both the methanol extract of the root of Astragalus as astramembrainina I (saponin isolated from the root), have anti-inflammatory properties in some experimental models in vivo, both orally and intravenously.

3 -. Immunostimulatory properties. One of the most important properties of this species is its ability to enhance the immune response. In vivo assays performed with Astragalus polysaccharides increased response in mice after parenteral administration of a polysaccharide purified from aqueous extract was observed. The astragalanos I and II have a variety of effects in mice when administered intraparenteralmente such as increased weight and number of spleen cells and their response to sheep red blood cells and stimulation of the phagocytic activity of peritoneal macrophages However some of these effects do not occur when administered orally or intravenously. Administration of extracts of Astragalus enhances the cytotoxic response of specialized cells, increasing from 5 to 6 times its response. Cell phagocytosis of reticuloendothelial system is also intensified, increasing the activity of T lymphocytes, stimulated.

the natural production of interferon and enhances its activity. Although it has anticancer properties, improves the response in patients treated with antineoplastic potency as drug response and reduces the adverse effects thereof. In experiments with astragalán, longer survival was obtained in the group of animals treated with the polysaccharide.

4 -. Antiviral properties. Astragalán has antiviral properties, and that inhibits the replication of some viruses, such as coxsackie. In other viral infections such as chronic viral hepatitis or HIV, has been shown the positive effect, but due to the increase of the immune response, not the antiviral effect.

5 -. Antibacterial properties. Not directly inhibit the growth of bacteria, but protects against the effects of endotoxin from Escherichia coli, also acts to increase the response in infections caused by Shigella, Streptococcus, Staphylococcus and Diplococcus.

6 -. Cardiovascular effects. Other credits include the hypotensive properties of astramembrainina I, administered intravenously in cats and dogs. Saponins have anticoagulant properties. There are references on the use of the root of Astragalus in traditional Chinese medicine in cases of stroke, congestive heart failure and angina pectoris, with good results.

Directions

Astragalus root is indicated for the treatment of patients with compromised immune system, viral infections and patients with hypertension problems. You can decrease the immune hyperactivity in patients with systemic lupus erythematosus and myasthenia gravis so its use is recommended in these cases.
It can also be applied to patients with AIDS, viral hepatitis, peripheral vascular disease, immune disorders and hypertension. It is also used in asthma, peptic ulcer, respiratory disorders, diarrhea and infections generally caused by Diplococcus, Staphylococcus and Streptococcus. In Chinese medicine is also used for diabetes, heart disease and Alzheimer's disease.

Contraindications

Although not described effects in pregnant or lactating, you should avoid using Astragalus during pregnancy and lactation. You do not have mutagenic effects. According to the experimental and clinical data there are no restrictions on its use, but should be used with caution in patients receiving immunosuppressive therapy (transplant or autoimmune diseases) and in patients who are to undergo surgical anesthesia.

Side Effects

No reported side effects at therapeutic doses.

Caution / Poisoning

Interactions acyclovir power effects, interleukin 2 (IL-2) recombinant and recombinant alpha (IFN alpha and IFN alpha-1-2) interferon. You can file incompatibility with immunosuppressive agents (cyclosporine, azathioprine and methotrexate). With anticoagulants, antiplatelet and antithrombotic agents, powder or extract Astragalus may increase the risk of bleeding. You can decrease the effect of oral hypoglycemics. Other possible interactions described are: phenobarbital, beta-blockers and some nasal decongestants.
Some traditional Chinese medicine books recommend not using at the beginning of acute conditions such as colds or flu, especially when there is high fever. No toxic effects have been reported. The polysaccharides may stimulate the release of histamine, so can aggravate any allergic symptoms. The LD50 for Astragalus intraparenteral in rats is greater than 40 g / kg. Repeated doses of 0.5 g / kg for 30 days no manifiestaron any toxic symptom.
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An essential place in traditional Chinese medicine.

Astragalus (Astragalus membranaceus) - Huang Qi - is a plant of northeastern China that grows on the edge of forests. The roots are harvested only when they are four or five years. Then dried and cut into slices or sliced ​​with tisanes to do.

Astragalus occupies a place of choice as superior tonic and is prescribed for hundreds of years to treat a range of diseases, to prevent weakening of the sick and protect against infection.
A Russian physician, Dr. Alexander van Bunge, who was described and studied for the first time this legume in 1868, but will be from the 70's when extensive scientific studies confirming its many properties.

¤ Restorative and stimulating the immune system

¤ Astragalus increases the number of stem cells in the bone marrow and lymph tissue and encourages their development into active immune cells. Reactive resting immune cells, produce immunoglobulins, stimulates macrophages and promotes the regeneration of the T cells and activation of natural killer cells (Natural Killer).

¤ On the other hand, induces endogenous interferon production and enhances their actions in viral infections.
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¤ Finally, this plant has been traditionally used in China as "support" of chemotherapy treatments because they enhance resistance to immunosuppressive effects of anticancer drugs to induce macrophages to produce interleukin-6 and necrosis factors tumor. It is therefore fully specified to limit the toxicity of chemotherapy, it helps to strengthen the defenses of people with cancer, which helps to recover quickly while offering them the ability to live longer.

¤ An increase in life expectancy

But its virtues do not stop here, as the talus could allow lengthen life, which can only be understood after examining its components ... In fact, it contains flavonoids, polysaccharides and triterpene glycosides, including astragaloside cicloastragenol IV and which have the ability to stimulate telomerase in keratinocytes, fibroblasts and the immune cells in culture and prolong shorter telomeres. The astragaloside IV and cicloastragenol are cutting edge anti-aging substances. The extremely high cost of extraction may, unfortunately, discourage wider use.

Thus the hidroglicerinado extract of the whole plant is particularly interesting, since it contains only small doses these valuable substances, but also offers the synergistic action of other plant components.

More accessible than the astragaloside iv or cicloastragenol, Astragalus Extract allows it to offer everyone the hope of greater health benefits associated with its ancient traditional use.

Cardioprotective and neuroprotective effects

In vitro, the talus has the ability to inhibit by 40% lipidic peroxidation in the myocardium and thus represents a powerful antioxidant able to protect the heart from oxidative stress. Studies have shown its beneficial effects on people with congestive heart failure or angina pectoris.

In addition, traditional Chinese medicine uses astragalus root extract to alleviate neurodegenerative diseases.

Adaptogens effects

¤ Also this plant is often used in Chinese medicine to help protect the body from many types of stress, whether physical, mental or emotional.

¤ addition, according to studies, Astragalus also has the ability to reduce inflammation and protect the liver.

¤ According to an anecdote, but only well-documented report, the topical use of a hidroglicerinado astragalus extract, combined or not with oral intake of astragaloside iv, allowed, after several months, return the original color to gray hair.

Article Wiki Closed - Astragalus: Benefits, Reviews, Warnings?
asked Jun 10, 2014 by Lancomega Level (10,245 points)
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