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Saw Palmetto: Benefits, Uses, Effects?

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Saw Palmetto: Benefits, Uses, Effects?
Serenoa repens - SAW PALMETTO - SABAL SERRULATA
Effects of saw palmetto in men with symptomatic benign prostatic hyperplasia.

Purpose: I've been tested the effects of saw palmetto in men with benign prostatic hyperplasia (BPH) symptomatic through a test with placebo control.

Materials and methods: The test was performed on 44 men aged between 45 and 80 years, with symptomatic BPH, using a mixture of saw palmetto versus a placebo. The effects were assessed by routine clinical measurements (symptoms, urinary flowmetry, residual urine volume), chemical studies on blood (prostate-specific antigen, analysis of sex hormones), prostatic volume by MRI and biopsy.
Results: Both groups under control showed an improvement in the clinical profile, with a small advantage in favor of the Saw Palmetto, albeit not statistically significant. The mechanism of action appeared to be non-hormonal, but it was not identified. Not become noticeable side effects.

Conclusions: Saw Palmetto is a safe and desirable for people with moderately symptomatic BPH. The clinical effects obtained with the administration of Saw Palmetto were only slightly better than the control group (placebo). However in the treated group it was noticed a certain degree of epithelial contraction, especially in the transition zone, which indicates a possible positive activity.

Efficacy and safety of the extract of Serenoa repens in the treatment of BPH.

Authors: J Braeckman, Bruhwyler J, Vandekerckhove K, J Géczy
Source: Phytotherapy Research. 1997; 2:558-563.

The study aims to assess the efficacy and safety of two different doses, 160 mg once daily and 320 mg divided into two daily intakes, extract of Serenoa repens administered for a period of one year in 132 patients with benign prostatic hyperplasia (BPH).

Both doses induced a significant improvement in the clinical situation:
No Prostatic Symptoms (60% after one year)
n Quality of life (85% of patients declared themselves satisfied after one year of therapy)
No prostate volume (12% after one year)
No residual urine volume (16% after one year)
Was not shown significant differences between the two doses.

The percentage of patients who complained of an average or low tolerance to the treatment was not greater than 4%.
19 side effects were observed in 16 patients (12.1%), 8 in each group.
The majority of these side effects (at least 75%) was still connected to the natural evolution of the disease rather than the treatment.

It can be concluded that the extract of Serenoa repens, in both doses, is safe and effective on urination problems associated with BPH. As a result, it offers a viable alternative to pharmacological treatment in patients with BPH of mild or moderate severity.

Ineffectiveness of an extract liposterolic Serena repens on plasma levels of testosterone, follicle-stimulating hormone and luteinizing hormone.

Authors: Casarosa C, Coscio MC, Fratta M.
Source: Clinical Therapeutics. 1988; 10 (5) :585-588.

Twenty men between the ages of 50 and 75 years (mean: 67 years), suffering from benign prostatic hypertrophy, took 160 mg of extract of Serenoa repens liposterolic, twice a day for 30 days.
Before and after treatment titolarono plasma levels of testosterone, follicle-stimulating hormone and luteinizing hormone.
It is not determined quantitative differences between the two titrations.
It can be concluded that the extract, although useful in the treatment of benign prostatic hypertrophy, does not cause systemic changes in hormone levels.

Long-term treatment of benign prostatic hyperplasia using Sabal serrulata extract IDS 89.

Authors: Bach D, Ebeling E.
Source: Phytomedicine. 1996; 3 (2) :105-111.

The study was done on a 3-year treatment using Sabal extract IDS 89, to evaluate the efficacy and limitations of its use as a pesticide in the treatment of BPH.
The results obtained from 435 patients confirmed its continued efficacy.
It was observed a marked improvement of symptoms, including a reduction of 50% of the residual urine and an increase of 6.1 ml / sec peak urinary flow.

Both physicians and patients judged its effectiveness as good or very good in over 80% of cases, the treatment was also well tolerated by 98% of patients.
The clinical status and quality of life improved markedly in 4 of 5 patients.
Furthermore, the ratio of deterioration at the end of the three years of therapy was significantly lower than the untreated subjects.

It can be concluded the long-term therapy may also reduce the incidence of surgery.

Effectiveness of saw palmetto extract on prostate tissue of patients with symptomatic BPS.

Authors: Epstein J, Partin A, Simon I, Kyprianou N, Hess D, Prins G, Marks L, Dorey F, Macairan M, Santos P.
Source: American Urological Association 94th Annual Meeting; May 1-6, 1999; Dallas, Texas.

Introduction: The mechanism of action of saw palmetto extract (SPE) on human prostate is unknown. One of the most acclaimed mechanisms is based on the inhibition of the action of androgen and an anti-inflammatory effect.
These possibilities were evaluated by studying samples obtained by biopsy of the prostate before and after treatment with SPE and placebo control period of six months.

Methods: The study was performed on 41 men who at the beginning of the test was taken a biopsy of the prostate. 21 patients took the SPE, while 20 patients took a placebo. At the end of treatment, the duration of 6 months, the other 41 samples were taken, for a total of 82.
They were studied by routine histology, quantitative morphometry of tissue composition of the inner and outer layers of the gland, histopathological evaluation of acute and chronic inflammation and atrophy, cell proliferation, the level of testosterone and dihydrotestosterone (expressed in ng / g prostate tissue).

Results: In the group treated with SPE reply, after 6 months of treatment, a contraction of the epithelium of the transition zone from 17.8% to 10.7%.
In a parallel analysis, but independent, epithelial atrophy, increased from 25.2% to 40.9%.
In the placebo group did not revealed any significant changes in tissue measurement.

Conclusions: The SPE seems to be able to exert a suppressive effect on the epithelium prostate, especially at the level of the transition zone. Since there was evidence of any alteration prostatic androgen metabolism, the data suggest that the effect is due to a non-hormonal control mechanism.
It is not clear how the suppression epithelial, in the absence of a volume contraction of the prostate, may be related to the clinical effects. However, the fact that the SPE will in 6 months lead to a decline epithelial statistically significant, it should serve as a stimulus to continue the research.

Extracts of Saw Palmetto in the treatment of benign prostatic hyperplasia.

Authors: Wilt TJ, Ishani A, Gerold Stark G, MacDonald R, Lau J, Mulrow C.
Source: JAMA. 1998; 280:1604-1609.

Objective: To conduct a systematic study and, when possible, a quantitative meta-analysis of the evidence of the therapeutic efficacy and safety of the extract of saw palmetto (Serenoa repens) in men with symptomatic benign prostatic hyperplasia (BPH).

Data Sources: Studies were identified by searching MEDLINE (1996-1997), EMBASE, Phytodok, the Cochrane Library, bibliographies of identified trials, articles, and contacts with influential authors and pharmaceutical companies.

Studio: On patients with symptomatic BPH was used a preparation of Serenoa repens alone or associated with other phytotherapeutic agents and a control group received a placebo or other pharmacological therapies for BPH. The duration of the treatments was at least 30 days.

Extrapolation of the data: Two researchers extrapolated for each item independently key data.

Data Synthesis: It was analyzed a total of 18 studies involving 2939 men. Many of these studies gave results that did not allow a meta-analysis. The average duration of the studies was 9 weeks (with extremes from 4 to 48 weeks).
Patients who received a pesticide, compared with those who took the placebo showed a decrease in urinary tract symptoms and nocturnal incontinence and an improvement in urine flow.
Compared with subjects treated with finasteride, there was a similar improvement in the level of urinary tract symptoms and urinary flow.
Side effects due to Serenoa repens were mild and infrequent; erectile dysfunction was more frequent in patients treated with finasteride than in those under treatment with Serenoa repens.
Conclusions: The available literature on Serenoa repens used in the treatment of BPH is rather limited due to the short duration of the studies, variability in the design of the studies, due to the use of different preparations fitoterapeutiche and the different ways to interpret the data collected.

In any way, there is a clear evidence of the efficacy of Serenoa repens in improving urologic symptoms and flow measurements.
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Compared with finasteride, it leads to an improvement of the clinical situation very similar, with fewer side effects.

Future research will need standard preparations of Serenoa repens, because only then you will be able to determine the long-term efficacy for the prevention and treatment of BPH.

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