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Coenzyme Q10: Health Benefits, Side Effects, Uses, Dosage, Warnings?

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Coenzyme Q10: Benefits, Side Effects, Uses, Dosage, Warnings?

The coenzyme Q 10 ( CoQ 10 , or simply Q 10 ), also known under the name of ubiquinone , is a 1,4-benzoquinone in which Q refers to the group quinone and 10 units to isoprene in the chain side.
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This substance, like a vitamin soluble , is present in most cells eukaryotes , primarily in the mitochondria , where it is involved in the respiratory chain in the context of cellular respiration aerobic .

Summary [ hide ]
1 Biochemistry
2 History
3 Physiological Roles
4 Therapeutic role
5 Chemical Synthesis
6 References
Biochemistry [ change | change the code ]
In its pure form, CoQ 10 is an orange-yellow crystalline powder, odorless, tasteless. It is partly absorbed with our food , but is also produced in the body itself. This coenzyme present in all cells human, involved in the transformation of the energy supplied by the power in energy usable by the cell. Only after this processing, performed in the mitochondria , the energy contained in the food may be used by the human body. 95% of body energy needs are processed using CoQ 10 3 , ​​4 . The bodies requiring more energy - such as the heart , the lungs and the liver - also have rates CoQ 10 highest 5 . CoQ 10 is very important for the human body and can not be replaced by any other substance.

CoQ 10 diffuses freely in the lipid bilayer as it is a benzoquinone which is soluble in lipids with a long-chain isoprenoid .

History [ edit | edit the code ]
CoQ 10 was discovered there over 40 years 6 . For several years now, this vital substance is known and appreciated as an essential supplement.

Physiological roles [ change | change the code ]
Following his discovery of the significant role of CoQ 10 in the production of energy, the British scientist Peter Mitchell received the Nobel Prize in Chemistry in 1978, CoQ 10 is indeed involved in the respiratory chain , which provides energy used by the cell as' d ATP . It is an intermediate which has the ability to cycle between an oxidized form and a reduced form, and therefore to transfer electrons from an enzyme complex to another (NADH-dehydrogenase cytochrome reductase). Further Some believe that CoQ 10 , which would have a role as an antioxidant , would protect our cells against the effects of free radicals supposed destructive [ref. insufficient] .

Of interest to the sport, it was shown that if you increase dietary supplement intake of CoQ 10 from 60 to 100 mg / day for 4-8 weeks the exercise capacity is increased [ ref. desired] . 's heart rate improved in cardiac patients, lipid metabolism is more efficient and maximal oxygen uptake (Vo2max) and time to the treadmill 7 [ref. insufficient] .

Reducing the rate of CoQ 10 is associated with aging 8 , as well as factors such as extreme physical exertion, the stress , increased consumption of alcohol and tobacco, as well as in specific diseases. Some drugs reduce the rate of cholesterol (called " statins ") also inhibit the natural production of CoQ 10 in the body without having a negative role demonstrated 9 . Low levels of this molecule would be correlated with a worse prognosis in a heart failure 10 but this remains controversial 9 .

Therapeutic role [ change | change the code ]
Our diet provides us with a daily intake of about three to ten milligrams of this Coenzyme 11 . However, there may be a normal diet is insufficient to meet the body's requirements for CoQ 10 . Statins, drugs that block the formation of cholesterol and liver secondarily the production of ubiquinone deficiency can cause 12 . When our need for CoQ 10 increases, a dietary supplement may help avoid a shortage.

Coenzyme Q10 is mainly present in meat and fish. Vegetables and dairy products contain relatively few 13

CoQ10 content of foods
in g / 100 g fresh material 14
Foodstuffs Kamei
(1986) Weber
(1997) Mattila
(2001) Kubo
(2008)
Beef 3100 3100 3650 3030-4010
Chicken 2100 1700 1400 1710-2500
Fish 550-6430 430-2700 850-1590 180-13000
Broccoli 860 660 ... 701
Potato 100 52 50 105
Egg 370 150 120 73
Chemical synthesis [ change | change the code ]
Three different methods are implemented for the production of CoQ 10 : the fermentation of yeast , bacterial fermentation and chemical synthesis . The fermentation process results in a yeast CoQ 10 configuring all- trans , which means that it is identical to the CoQ 10 naturally found in meat , the fish and other products.

The safety of the yeast fermentation was confirmed by various studies carried out by a security control laboratories the world's most famous ( Covance Laboratories Inc.) 15 . In addition, a test randomized (random) double blind control placebo , (a typical pharmaceutical protocol) showed that the fermentation of yeast is safe and well tolerated up to 900 milligrams per day.

CoQ 10 produced by chemical synthesis also generates isomer cis (the structure of a configuration molecular that are not found in the CoQ 10 natural).

Recently there is a CoQ 10 lipophilic and hydrophilic micelle with a bioavailability greater 16 .

General Information

Coenzyme Q10 is an antioxidant, meaning it protects body cells against the harmful effects of oxygène.Elle is found throughout the body - especially the heart, liver, kidneys and muscles - and is necessary for the proper functioning of our cells. Our body produces this antioxidant, and the food we eat (eg. Meat, seafood) may also provide us with a small amount.

Common Name

coenzyme Q10, ubiquinone 10, CoQ10, Ubidecarenone
Scientific name

coenzyme Q10, ubidecarenone
How does this product usually used?

Generally, coenzyme Q10 supplements are taken by mouth; they are available in various forms: tablet, capsule, powder and liquid.

The majority of commercial products containing coenzyme Q10 are made from yeast.

Your health care provider may have recommended this product against other ailments. Contact a healthcare professional if you have any questions.

For what purpose is this product does he use?

Is used for coenzyme Q10:

maintain and support cardiovascular health (eg reducing the risk of heart failure, high blood pressure or heart attack.)
prevent migraines and nausea and vomiting that accompany them;
maintain good health due to its antioxidant properties.
According to preliminary data, coenzyme Q10 supplements may be beneficial for people who have heart failure for many years. This antioxidant should never be used alone to treat heart failure, but it can be useful if taken with other medications to treat it. Taking coenzyme Q10 soon after a heart attack can reduce the risk of having another heart attack; however, other studies are needed to verify the actual effects.

Supplements can also be beneficial for people who have high blood pressure.

Coenzyme Q10 may reduce migraine frequency and the average number of days of sickness-related headache. You may need to take coenzyme Q10 for 3 months before improvement begins to manifest. If there is no improvement, or if your migraine symptoms worsen, consult your doctor.

We also studied the use of coenzyme Q10 to treat other disorders, including:

diabetes;
gum disease;
Parkinson's disease;
Huntington's chorea;
side effects caused by some drugs;
HIV and AIDS;
certain cancers;
Alzheimer's disease.
The studies of people with diabetes have had mixed results; in fact, it is not known whether coenzyme Q10 would succeed in controlling the blood sugar levels of all diabetics.

The efficacy of Coenzyme Q10 on the gums used to treat gum disease has not been demonstrated. However, it is possible that the presentation of coenzyme Q10 taken by mouth provide some benefit.

According to some studies, coenzyme Q10 may slow the progression of Parkinson's disease in its early stages. By cons, those made at an advanced stage of the disease might not benefit from this antioxidant treatment. Coenzyme Q10 does not seem effective in people with Huntington's disease.

Taking Coenzyme Q10 could improve immune function in people with advanced human immunodeficiency virus (HIV) or suffering from acquired immune deficiency syndrome (AIDS).

Moreover, according to the first results of studies on the subject, coenzyme Q10 may slow the progression of Alzheimer's disease, but further studies should be conducted.

The drugs (also called statins) belonging to the class of HMG-CoA reductase , and which serve to lower the blood cholesterol can reduce the amount of coenzyme Q10 in the blood. However, at present, we do not have enough data to support the recommendation to routinely give coenzyme Q10 in patients treated with a statin (either as a supplement or prevent muscle damage that can be caused by low levels of coenzyme Q10). In addition, research to support taking supplements of coenzyme Q10 by people who receive certain anticancer drugs (eg. Doxorubicin) in order to reduce potential adverse effects of these products on the heart remain too few.

Your health care provider may have recommended this product against other ailments. Contact a healthcare professional if you have any questions.

Should I realized that something else?

Coenzyme Q10 is safe for most adults. The following side effects have been reported: a mild stomach upset, loss of appetite, nausea, vomiting, low blood pressure and diarrhea . Spreading the doses throughout the day may reduce these side effects.

Because coenzyme Q10 is an antioxidant, it is concern whether it could reduce the effectiveness of certain cancer drugs (chemotherapy) when both are used together; so consult a health professional before taking coenzyme Q10. Finally, coenzyme Q10 may interact with warfarin and antihypertensive drugs. Consult your doctor if you are taking any of these drugs.

You should avoid using coenzyme Q10 if you are pregnant or breastfeeding or if you are suffering from a liver disorder.

You need to stop taking any supplement coenzyme Q10 at least 2 weeks prior to surgery (to avoid problems controlling blood pressure).

Before taking any new medications, including natural health products, speak to your doctor or pharmacist, or other health care professional. Tell your healthcare professional of any natural health product which you use.

Coenzyme Q10, also called CoQ10 or ubiquinone, is one of the necessary energy substances in the cells of almost all living things. It has strong antioxidant properties. His blood level decreases with age and in people who take statins (drugs against excess cholesterol ).
Decision of the European health authorities in 2012
In 2012, the European health authorities (EFSA, European Food Safety Authority and the European Commission) have ruled on some health claims for dietary supplements containing coenzyme Q10 (ubiquinone). After a review of evidence, they felt that these products may NOT qualify:
prevent fatigue, support physical or intellectual effort, or help maintain mental function;
increase the quality of life of cardiac patients;
reduce the risk of cancer ;
support recovery;
help maintain normal blood pressure or rate of cholesterol normal;
help fight against free radicals responsible for aging (antioxidant effect).
These claims are now banned effect for dietary supplements containing coenzyme Q10 (ubiquinone).
Uses and properties of coenzyme Q10 supposed
tobacco leaves
Like many antioxidants , coenzyme Q10 is present in supplements to protect the heart and blood vessels. It is also found in those in the fight against aging. It is also proposed to fight against periodontal disease (tissue attaching the teeth to the gums) and to offset the effects of statins on blood levels of coenzyme Q10.
How effective for coenzyme Q10?
Japan, Israel and other countries, coenzyme Q10 is a drug available on prescription for people suffering from heart failure chronic. It is also prescribed before cardiac surgery to improve the strength of the heart muscle to decreases in oxygen supply.
Some studies have shown a positive effect on periodontal infections. In contrast, no effect on aging, on weight loss or on athletic performance has never been observed. Finally, several serious studies suggest that during treatment against the cholesterol with statins, simultaneous administration of coenzyme Q10 could improve the effectiveness of treatment.
European health authorities have not ruled on these uses. But they have banned several health claims (see box above).

Precautions Coenzyme Q10
Pregnant or nursing women should avoid taking coenzyme Q10.
People taking anticoagulants should be cautious because this substance could reduce the effectiveness of their treatment.
People with type 2 diabetes should monitor their blood sugar because of hypoglycemia were observed in these patients.

Possible side effects of this substance are nausea and diarrhea .
Original forms and dosage of coenzyme Q10
The coenzyme Q10 is extracted from tobacco leaves and the fermentation of cane sugar or beet.
The doses used in clinical trials was 100 to 150 mg per day.
Coenzyme Q10 is found primarily in fish and meat, lamb and beef in particular.
The expert's opinion on coenzyme Q10
Coenzyme Q10 is poorly absorbed by the intestine (less than 40% of the ingested dose), which limits its use.

Coenzyme Q10

General Information

Coenzyme Q10 is an antioxidant, meaning it protects body cells against the harmful effects of oxygène.Elle is found throughout the body - especially the heart, liver, kidneys and muscles - and is necessary for the proper functioning of our cells. Our body produces this antioxidant, and the food we eat (eg. Meat, seafood) may also provide us with a small amount.

Common Name

coenzyme Q10, ubiquinone 10, CoQ10, Ubidecarenone
Scientific name

coenzyme Q10, ubidecarenone
How does this product usually used?

Generally, coenzyme Q10 supplements are taken by mouth; they are available in various forms: tablet, capsule, powder and liquid.

The majority of commercial products containing coenzyme Q10 are made from yeast.

Your health care provider may have recommended this product against other ailments. Contact a healthcare professional if you have any questions.

For what purpose is this product does he use?

Is used for coenzyme Q10:

maintain and support cardiovascular health (eg reducing the risk of heart failure, high blood pressure or heart attack.)
prevent migraines and nausea and vomiting that accompany them;
maintain good health due to its antioxidant properties.
According to preliminary data, coenzyme Q10 supplements may be beneficial for people who have heart failure for many years. This antioxidant should never be used alone to treat heart failure, but it can be useful if taken with other medications to treat it. Taking coenzyme Q10 soon after a heart attack can reduce the risk of having another heart attack; however, other studies are needed to verify the actual effects.

Supplements can also be beneficial for people who have high blood pressure.

Coenzyme Q10 may reduce migraine frequency and the average number of days of sickness-related headache. You may need to take coenzyme Q10 for 3 months before improvement begins to manifest. If there is no improvement, or if your migraine symptoms worsen, consult your doctor.

We also studied the use of coenzyme Q10 to treat other disorders, including:

diabetes;
gum disease;
Parkinson's disease;
Huntington's chorea;
side effects caused by some drugs;
HIV and AIDS;
certain cancers;
Alzheimer's disease.
The studies of people with diabetes have had mixed results; in fact, it is not known whether coenzyme Q10 would succeed in controlling the blood sugar levels of all diabetics.

The efficacy of Coenzyme Q10 on the gums used to treat gum disease has not been demonstrated. However, it is possible that the presentation of coenzyme Q10 taken by mouth provide some benefit.

According to some studies, coenzyme Q10 may slow the progression of Parkinson's disease in its early stages. By cons, those made at an advanced stage of the disease might not benefit from this antioxidant treatment. Coenzyme Q10 does not seem effective in people with Huntington's disease.

Taking Coenzyme Q10 could improve immune function in people with advanced human immunodeficiency virus (HIV) or suffering from acquired immune deficiency syndrome (AIDS).

Moreover, according to the first results of studies on the subject, coenzyme Q10 may slow the progression of Alzheimer's disease, but further studies should be conducted.

The drugs (also called statins) belonging to the class of HMG-CoA reductase , and which serve to lower the blood cholesterol can reduce the amount of coenzyme Q10 in the blood. However, at present, we do not have enough data to support the recommendation to routinely give coenzyme Q10 in patients treated with a statin (either as a supplement or prevent muscle damage that can be caused by low levels of coenzyme Q10). In addition, research to support taking supplements of coenzyme Q10 by people who receive certain anticancer drugs (eg. Doxorubicin) in order to reduce potential adverse effects of these products on the heart remain too few.

Your health care provider may have recommended this product against other ailments. Contact a healthcare professional if you have any questions.

Should I realized that something else?

Coenzyme Q10 is safe for most adults. The following side effects have been reported: a mild stomach upset, loss of appetite, nausea, vomiting, low blood pressure and diarrhea . Spreading the doses throughout the day may reduce these side effects.

Because coenzyme Q10 is an antioxidant, it is concern whether it could reduce the effectiveness of certain cancer drugs (chemotherapy) when both are used together; so consult a health professional before taking coenzyme Q10. Finally, coenzyme Q10 may interact with warfarin and antihypertensive drugs. Consult your doctor if you are taking any of these drugs.

You should avoid using coenzyme Q10 if you are pregnant or breastfeeding or if you are suffering from a liver disorder.

You need to stop taking any supplement coenzyme Q10 at least 2 weeks prior to surgery (to avoid problems controlling blood pressure).

Before taking any new medications, including natural health products, speak to your doctor or pharmacist, or other health care professional. Tell your healthcare professional of any natural health product which you use.

Article Wiki Closed - COENZYME Q-10: Benefits, Side Effects, Uses, Dosage, Warnings?
asked Aug 13, 2014 by Lancomega Level (10,245 points)
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