Coenzyme Q10: Benefits, Side Effects, Uses, Dosage, Warnings?
Coenzyme Q10, anti-aging supplement of choice!
This is a transcript of an interview with Dr. Robert Barry, who is an active member of numerous medical associations including the American Chemical Society and the American Association for the Advancement of Science. He specializes in the field of cooperation and development in clinical research and the marketing of products and technologies commercially. Dr. Barry explained by the difference between two forms of coenzyme Q10 ubiquinone and ubiquinol. Coenzyme Q10 is well known for its role in the proper functioning of our "central cellular energy" are our mitochondria, and its importance for optimal health and longevity.
Why take a supplement of coenzyme Q10?
Dr. Barry: There is a good reason why CoQ10 is one of the most popular dietary supplements and more sold on the market, and this is mainly because it is a metabolic agent very effective and when people use it, they see a good improvement in their health, especially in terms of their energy.
The basic function of coenzyme Q10 is to generate metabolic energy. It is an essential component in the chain of the mitochondria electron transport, which facilitates the generation of ATP (adenosine triphosphate). The mitochondrion is responsible for producing about 95% of ATP in the body, CoQ10 is an essential component of this activity. It should be noted that ATP is a prerequisite for all human and animal life on the planet molecule.
In what forms does coenzyme Q10 and what is the difference between the two?
Dr. Barry: The coenzyme Q10 supplements come in two forms: ubiquinone and ubiqunol. The main difference between the two is that the ubiquinol has antioxidant properties, which is not the case with ubiquinone.
Since ubiquinol has two extra electrons and can give them, it is a powerful fat-soluble antioxidant ... powerful enough to regenerate vitamin E and vitamin C in the body ... which is a vital role of CoQ10. CoQ10 has other utilities such as gene expression and cell signaling. But its two main functions are the production of cellular energy and protection of all body cells.
When we try to understand the real difference between ubiquinol (known scientifically as the "reduced" form of CoQ10) and ubiquinone (oxidized form of CoQ10), it is easier to compare two other antioxidants: vitamin E and vitamin C. In essence, take ubiquinone, would be like taking vitamin C or vitamin E oxidized - which would not be very useful since the oxidized vitamins lose their antioxidant power. Ubiquinone therefore not the same as ubiquinol antioxidant capacity that has excess electrons.
What form of CoQ10 offers the best value for money?
Dr. Barry: So far, studies have shown that ubiquinol bioavailability was greater with ubiquinol compared to that of ubiquinone. It is true that ubiquinol is more expensive, but this form of CoQ10 offers better value for money than ubiquinone (Conventional CoQ10) because a smaller amount is needed to get the same results. Better absorption that you need only one-third the amount of ubiquinol compared to ubiquinone.
Ubiquinol is it easier to absorb and an overdose can it be toxic?
It is very interesting to note that although this is a fat-soluble antioxidant (soluble in fat) - which usually means that it is more difficult to absorb - ubiquinol is "special" because its rate of absorption appears to be related to the metabolic demand - which is fantastic! This would mean that when you are healthy, you absorb less, and when you are sick or struggling with a chronic illness, your body will absorb a greater amount. This absorption rate is essentially self-adjusting, so it becomes very difficult to take excessive dose.
That said, given that ubiquinol is lipid soluble, it must be taken with food - or, for example, with a little peanut butter or olive oil - and this for sure you have a bio-availability and optimal absorption.
As regards product safety, the two versions are virtually identical. The non-oxidized form, ubiquinol - has the same safety profile as ubiquinone (conventional form), which is very reassuring. So there is no known side effects or drug interactions, and both are recognized as safe even when taken in large quantities.
Better, several studies have demonstrated that both forms of CoQ10 are absorbed and metabolized in exactly the same way that CoQ10 food source, the main sources are meat and fish, and green leafy vegetables.
Regarding the dosage, studies suggest that coenzyme Q10 should ideally be used regularly over long periods. Studies also recommended to take 200 to 300 mg of CoQ10 per day (preferably in two divided doses) for optimal plasma level after 2 to 3 weeks. Then you can reduce to a maintenance dose of 100 mg per day. If you are very ill or chronically ill, you can keep going longer the initial dose.
Coenzyme Q10 can it help slow aging?
One of the most important benefits of CoQ10 based on its potential for slowing the aging process. And the evidence is very convincing that Ubiquinol is the form of CoQ10 to support to get this result!
A powerful example of the anti-aging effects of ubiquinol is a groundbreaking study on mice, which was conducted by researchers at a major medical center in Japan. Mice specially selected for the study and age very quickly have been used to test both forms of CoQ10 against a control group receiving no supplementation. At the end of the study, when the mice had an age that corresponded to 90-100 years in humans, differences between the control group and the group taking the supplement ubiquinol were quite spectacular.
While mice in the control group were near death, the mice in the group with ubiquinol ran in all directions as adolescent mice, and the only difference is that they took ubiquinol since birth.
What we have found is that in almost all studies on the ubiquinol (and each was necessarily a direct comparison with ubiquinone), we observe a dramatic metabolic and physiological effect that we do not see with CoQ10 conventional (ubiquinone). This study shows that there is something different with ubiquinol.
In summary, we now know that Coenzyme Q10 plays a vital role in the production of ATP - which is the basic fuel for every cell in the human body. Without this vital cellular energy production, life is not possible. Our body produces coenzyme Q10 naturally and transforms it into ubiquinol, which is the most effective form of this nutrient. But as the body ages, not only the conversion becomes less efficient, but our cellular energy production (ATP) also decreases so that we become more susceptible to the harmful effects of aging; and much more likely to have an acute or chronic illness. It is therefore very important to keep these high energy levels. It's not only important to avoid serious or chronic illness ... Fatigue is among the top five complaints in adults ... there is a reason for that and it has to do with coenzyme Q10 in terms of energy production .
So it's not an optional thing that can work or not work, you may or may not need, it's absolutely crucial. You produce coenzyme Q10 in your body ... but this "natural production" declines with age. More importantly, if with age conversion of CoQ10 to ubiquinol becomes less than optimal, you will have health problems.
When a CoQ10 supplement is it appropriate or even necessary?
A coenzyme Q10 supplement is essential for people who take statins to lower their cholesterol. Drugs with statins are effective in reducing cholesterol levels, but they are not very selective. Also, statins inhibit a key enzyme (HMG CoA reductase), which shares a pathway with production of CoQ10. Therefore, statins also reduce the body's ability to produce CoQ10 and therefore ubiquinol, and once your supply of CoQ10 is depleted, you really put your heart health at stake. Remember that ubiquinol is absolutely vital for optimal energy production in every cell of your body, and your heart is one of the most demanding energy bodies. Given that statins decrease the level of ubiquinol, these drugs also induce premature aging through the whole body, including the cardiovascular system while ...
But ubiquinol is not only useful for those who take statins or for those who want to extend their quality of life in general. In the treatment of diseases such as Huntington's disease and Parkinson's disease, it was shown that the coenzyme Q10 decreased disease progression. Research over the years have also seen benefits for diseases such as:
Definition of the ATP in Wikipedia:
Adenosine-5'-triphosphate (ATP) is the molecule that, in the biochemistry of all known living organisms, hydrolysis provides the energy required by the chemical reactions of metabolism.
Definition of coenzyme Q10:
CoQ10 is naturally present in all human cells and ensures the production of body energy. The energy supplied by the power supply body is transformed into energy in the mitochondria, with CoQ10. It is only after processing that the energy contained in the food may be used by the human body. 95% of body energy needs are processed using CoQ10. The organs require the most energy - such as the heart, lungs and liver - also have the highest levels of CoQ10. CoQ10 is very important for the human body and can not be replaced by any other substance.