COENZYME Q10: Benefits, Side Effects, Uses, Dosage, Warnings?
CoQ10 in each cell of the body - Q10
Coenzyme Q10 (2,3-dimethoxy-5-methyl-6-decaprenyl 1,4-benzoquinone / C 59 H 90 O 4 ) is found in every cell of the body. The fat-soluble substance is also called ubiquinone, which freely translated means bedeutetwie "available everywhere." Coenzyme Q10, without the production of energy in the cell is not possible, and the cell dies. Primary Coenzyme Q10 acts as a cofactor in the oxidative phosphorylation (cellular respiration) in mitochondria *, the "power plants" of the cell. In addition, coenzyme Q10 is a powerful antioxidant and free radical scavenger importantly, contributes to the fact that cell membranes remain flexible, and prevents the oxidation of lipids in these membranes. Coenzyme Q10 is for the vitality of tissues and organs is of great importance.
Dietary supplementation with coenzyme Q10
Ideally, the body produces coenzyme Q10 in sufficient quantity. Coenzyme Q10 is also in small quantities in a variety of (mainly of animal) food before. In case of illness, obesity, stress, drug intake, not wholesome nutrition and congenital or acquired disorders in the body's synthesis, it may be that the formation of coenzyme Q10 is not sufficient to meet the demand. Furthermore, taking the body's production of coenzyme Q10 in all men with age. So the content of coenzyme Q10 is in the heart tissue of older people (77-81 years), only 43% of what is found in 19-21 year olds. (42) In addition to the decrease in coenzyme Q10 synthesis aging with an increase oxidative stress and a reduction in mitochondrial function is associated. In an animal experiment it was shown that mice live significantly longer if their diet Coenzyme Q10 is added. Moreover, they remain much more active. (43.51) It is conceivable that a long-lasting dietary supplementation with coenzyme Q10 on the aging process and life expectancy favorable effect. (51)
Organs and tissues that consume a lot of energy, such as heart, pancreas, liver, kidneys, immune system, nervous system and muscles, have a high content of coenzyme Q10. These structures are first affected in their function when the formation of coenzyme Q10 is no longer sufficient and decreases the energy production in the cells. Dietary supplementation with coenzyme Q10 therefore primarily supports the organs and tissues with high energy requirements. It has been demonstrated that Coenzyme Q10 is well absorbed from dietary supplements. (1) In soybean oil dissolved coenzyme Q10 has a similar bioavailability to as coenzyme Q10 in complex emulsified form. (2)
Coenzyme Q10 is an excellent dietary supplement for people with cardiovascular disease. Coenzyme Q10 supports the pumping capacity of the heart muscle by improving energy production in heart muscle cells, and protects the heart against oxidative damage. Since the heart consumes a lot of energy, a shortage of Coenzyme Q10 acts immediately. Coenzyme Q10 prevents the oxidation of LDL cholesterol (low density lipoprotein), an important step in the process of hardening of the arteries, and also reduces blood viscosity. Coenzyme Q10 assumes recycling of vitamin E, so that it can stand as an antioxidant available again.
Illnesses and situations in which the dietary supplement is useful with Coenzyme Q10:
Coronary heart disease and heart attack: . those Q10 occupy within three days after infarction coenzyme improve their prognosis significantly (3) persons who have been resuscitated after cardiac arrest, have a significantly greater chance of survival (measured after 3 months) and a better neurological prognosis if they receive both a slight hypothermia supplementation with coenzyme Q10 (250 mg on admission, then 3x daily 150 mg). (54)
Cardiomyopathy: This disease is associated with a CoQ10 deficiency in heart muscle; supplementation with coenzyme Q10 enhances the contraction of the heart muscle. (4,5,51)
Heart failure (decompensatio cordis): The greater the deprivation of the myocardium with coenzyme Q10, the greater are the problems associated with heart failure symptoms (eg, cyanosis, arrhythmias, edema, sweating, shortness of breath, exercise intolerance). The therapeutic efficacy of coenzyme Q10 in heart failure has been scientifically proven. (6,7,8,47) Dietary supplementation with coenzyme Q10 improves systolic pump function in chronic heart failure, especially when ACE inhibitors are used (angiotensins-converting enzyme inhibitors). (47)
Angina pectoris: CoQ10 protects the heart tissue from ischemia and improved the clinical picture, so less rapidly occur during physical exertion angina symptoms. (3,9,10)
Cardiac arrhythmias. (3:11)
Prevention of adriamycin -induced (oxidative) damage to the heart: This chemotherapeutic agent acts as well as other anthracyclines are toxic to the heart and other tissues, since free radicals are generated.
Heart surgery: . Supplementation with coenzyme Q10 improves the condition of the heart, ischemia / reperfusion injury is reduced by the operation, reduces the risk of cardiac arrhythmias and promotes recovery (12,13) In a clinical study, 120 heart patients received in the two weeks before the operation daily either 300 mg CoQ10 or a placebo. Supplementation led to a highly significant increase in the content of Coenzyme Q10 in the serum and in the mitochondria of the cardiac cells. The researchers demonstrated that the heart tissue was much less susceptible in vitro against ischemia / reperfusion injury. (13) Incidentally protects coenzyme Q10 all body cells from damage by a relative shortage of oxygen, for example, during a stay in the mountains and in lung and vascular disease.
Mitral valve prolapse: Coenzyme Q10 improves the condition of the heart in the event that bulge portions of the left sail flap in the left atrium. (5.14)
High blood pressure: Coenzyme Q10 promotes normal blood pressure. This has been shown in various scientific studies. (5,15,16,37,51) Maybe this is a better energy in the cell, membrane stabilization and trapping harmful peroxynitrite radicals in context. (51)
Atherosclerosis and hyperlipidemia: . coenzyme Q10 support the reduction of cholesterol and lipoprotein (a) content in the blood and acts against the oxidation of LDL (10,17,18) , the "good" HDL cholesterol (high-density lipoprotein) will on the other hand about. (18) statins and gemfibrozil, widely used medicine for high cholesterol levels, reduce the body's synthesis of coenzyme Q10 and can cause fatigue. (49)
Some patients with severely elevated triglyceride levels do not respond to treatment with fenofibrate; However, a combination of fenofibrate and coenzyme Q10 (150 mg per day) resulted in a study in a significant reduction of triglyceride, uric acid and lipoprotein (a) level. (47) Coenzyme Q10 as a feed additive in mice significantly reduces the occurrence of atherosclerosis. (62) has been shown in animal experiments that coenzyme Q10 in combination with vitamin E atherosclerosis better than counteracts the individual dietary supplement for yourself, too. (61)
Metabolic syndrome and diabetes
Dietary supplementation with coenzyme Q10 has a positive effect on various aspects of the metabolic syndrome (insulin resistance syndrome) and type 2 diabetes from: It contributes to the normalization of elevated blood pressure, improves blood sugar regulation, support insulin function, improve abnormal blood lipid concentrations and reduced oxidative stress. (10,19,20,21,37) is thought to contribute to degeneration of mitochondria in insulin-producing beta-cells for development of type 2 diabetes. (22) Coenzyme Q10 supports the function of beta-cells and insulin production, by improving the state of the mitochondria. Moreover, coenzyme Q10 assists in the prevention of diabetic complications.
Obesity and lethargy
Coenzyme Q10 supports weight loss because it improves the combustion of sugars and fats. Studies have shown that people who eat a lot and still stay slim, have more CoQ10 than people who grow rapidly.
Fatigue is often the underlying cause, however, is often difficult to ascertain. There is evidence that oxidative stress and mitochondrial dysfunction play a role. (51) If persistent fatigue, the nutritional supplement can help with coenzyme Q10 to improve energy production in cells.
The defense system
Infectious diseases and different age ailments are often the result of a failing immune system. When the body does not have enough coenzyme Q10, this affects the quality of the defense system. From animal experiments it is known that coenzyme Q10 * phagocytosis by macrophages * and the proliferation of granulocytes * stimulating. (23) In AIDS patients, the coenzyme Q10 level in the blood is reduced and correlates with disease severity. A food supplement containing 200 mg of coenzyme Q10 per day improved the ratio between T4-helper and T8 suppressor cells. (24.41)
Coenzyme Q10 protects cellular DNA from oxidative damage and helps to prevent a derailment of cell division. (31) cancer may be associated with decreased coenzyme Q10 concentration. This has been demonstrated in patients with myeloma *, * melanoma, brain tumors, and breast, lung, prostate, pancreatic, colon, and renal carcinoma. (32-36,38,39,51,52) A low coenzyme Q10 levels in melanoma patients with a poorer prognosis and greater risk of metastasis connected. (52) There is evidence that supplementation with coenzyme Q10 to fight breast cancer contributes (dose 90-390 mg per day) and improves the prognosis. (35,40) Coenzyme Q10 supports the immune system, especially if this is chronically overworked.
The mucous membranes
Coenzyme Q10 protects and strengthens all the tissues, including the mucous membranes and gums. Coenzyme Q10 helps with gum problems, if this is a deficiency underlies with coenzyme Q10. (25) The best result may be obtained if coenzyme Q10 applying directly to the gums. (26) Coenzyme Q10 protects by acting as an antioxidant, the gastric mucosa. The production of gastric mucus and the rapid cell division of the gastric mucosa depends on a sufficient supply of coenzyme Q10.
Neurodegenerative diseases and muscle diseases
The mitochondria in the brain cells of individuals with Parkinson's disease is limited to function and exhibit a low content of coenzyme Q10. Dietary supplementation with high doses of coenzyme Q10 (1200 mg / day), the progression of Parkinson's disease delay by 44% in the initial stage. Kog-nitive and motor skills go less quickly lost. (27) It should be investigated whether a dose of 2400 mg of
coenzyme Q10 per day results in individuals with Parkinson's disease to even better results. (55) A deficiency of coenzyme Q10 and a Mitochon-mitochondria dysfunction also occur in the hereditary forms of the following diseases: muscular dystrophy, familial cerebellar ataxia, Friedreich's ataxia, metabolic myopathy, Huntington's chorea and ALS (amyotrophic lateral sclerosis). (51) as a dietary supplement with coenzyme Q10 (doses of more 600 mg per day) is useful in various neurodegenerative diseases. (28,29,30,50,51) In laboratory studies, it has been demonstrated that Coenzyme Q10 formation and enlargement of the characteristic of Alzheimer's disease amyloid plaques inhibits and destabilizes existing plaques. (45) Coenzyme Q10 can therefore for the prevention and treatment of dementia are of great importance. (51)
In a clinical trial it was shown that coenzyme Q10 alleviates migraine. (44) A group of 42 patients took with migraine per day × 3 one 100 mg CoQ10 or a placebo. The intake of coenzyme Q10 resulted after three months in a significant decrease in the number and intensity of migraine attacks (incidence of stomach / intestinal symptoms, number of days with headache, intensity of headache). In 33% of subjects who took coenzyme Q10, the number of migraine attacks decreased by more than 50% in the placebo group this was the case for only 14%. In the course of the disease of migraine, the mitochondrial dysfunction play a role. The effect of supplementation was seen after one month and reached its maximum after three months.
Other areas of application
Other diseases in which the coenzyme Q10 levels may be partially greatly reduced and supplementation with coenzyme Q10 is useful to include anemia, asthma, vision problems, stroke and chronic renal failure. (51) persons with thalassemia-anemia (a hereditary form of chronic anemia) have more oxidative stress and a partially very low coenzyme Q10 levels. (58) Dietary supplementation with coenzyme Q10 increases in these people the antioxidant status and quality of life. Coenzyme Q10 protects the body from damage by free radicals. This incomplete molecules are formed to a greater extent during stress (chronic) diseases, aging, physical activity and the presence of toxins. A heavy load with free radicals leads to accelerated aging and the development or exacerbation of disease.
Safety and interactions
Coenzyme Q10 is a very safe dietary supplement. A dose of 1200 mg per day for 16 months was safe and was excellently tolerated; The same applied to a dose of 3000 mg per day over a period of 8 months. (27,48,50) In some cases, mild stomach / intestinal symptoms occur. Various drugs such as statins, oral antidiabetic drugs, beta blockers, tricyclic antidepressants, phenothiazines, methyldopa, hydrochlorothiazide, clonidine and hydralazine can the body's production of Coenzyme Q10 Lower - with undesirable consequences. The additional intake of coenzyme Q10 is advantageous. The pill and hormone replacement therapy during menopause can reduce coenzyme Q10 levels. (59,60) Dietary supplementation with coenzyme Q10 protects the kidney in animals from damage by gentamicin. (56) The strong decrease of coenzyme Q10 levels by 50 % through the use of atorvastatin was associated with side effects of statins such as exercise intolerance, myalgia * and Myoglobulinurie. (53) people with asthma who use corticosteroids for a long time, may be undersupplied with coenzyme Q10. A long-term use of corticosteroids can lead to mitochondrial dysfunction and oxidative damage to the DNA in the nucleus and mitochondrion. Dietary supplementation with coenzyme Q10 (120 mg per day) corrects this deficiency and can significantly reduce the effective dose of corticosteroids. (57)
The intake of coenzyme Q10 can theoretically reduce the effectiveness of warfarin. Also coenzyme Q10 can lower blood sugar levels. Diabetics must take into account this effect of coenzyme Q10.
Explanation of terms
Phagocytosis - the destruction of invading into the body as bacteria, viruses and other harmful elements by phagocytes (macrophages).
Granulocytes - White blood cells formed in the bone marrow and play a role in reducing harmful microorganisms.
Macrophages - (mononuclear phagocytes), cell type found in various places in the body and total forms the macrophage system. Macrophages have the ability to take up and degrade organic matter such as bacteria in itself.
Melanoma - proliferation of pigment cells in moles.
Mitochondria - rod-like or spherical organelles which have a double membrane and within the cytoplasm of the cell.
Myalgia - muscle pain
Myeloma - tumor extending from the spinal cord or bone marrow
Abbey coenzyme Q10
Important for energy production of the cells. Protects example, the cells of the skin from free radicals.
Abbey coenzyme Q10 Free radicals are produced mainly through stress, exercise and sunlight. You wear day after day to aging of cells and of the skin. Abbey coenzyme Q10 plus B-vitamins + zinc + Vitamin C + E helps protect and maintain the body's cells. Coenzyme Q10 has the function of an adjuvant for the energy transfer and release of energy especially in muscle cells, which consume a lot of energy. The vitamins B 2 , B 6 and B 12 also play an important role in energy metabolism. The essential trace element zinc makes an important contribution to the protection of body cells and thus contributes to the conservation eg skin cells. Abbey Coenzyme Q10 capsules also contain Vitamin E, which helps by binding free radicals, to stay healthy and fit. Abbey coenzyme Q10 plus B -Vitamins + zinc + C + E helps maintain the body's cells. Ingredients: gelatin; Soybean oil; hardened soybean oil; Coenzyme Q10; Vitamin E; Stabilizer glycerol; Vitamin C; Emulsifier soy lecithin; Zinc oxide; Vitamin B 2 ; Vitamin B 6 ; Dye Iron oxides and hydroxides; Vitamin B 12 ;
Nutrientsper capsule% Of rec. Daily dose per capsule *
Coenzyme Q1045 mg/ **
Vitamin E24 mg a-TE200%
Vitamin B 23.5 mg250%
Vitamin B 62.8 mg200%
Vitamin B 125 ug200%
Vitamin C12 mg15%
* Gem. Nutrition labeling regulations
** no recommendation available gluten free, without milk sugar Directions: 1 capsule daily with plenty of fluid (eg half glass of water.) swallow.
Food supplement with coenzyme Q10, zinc, vitamin E, vitamin B 2 , vitamin B 6 , vitamin B 12 , vitamin C. The recommended daily dose should not be exceeded. Dietary supplements are not a substitute for a varied and balanced diet and a healthy lifestyle. Protect from heat and sunlight.
Coenzyme Q10 GPH liquid
Coenzyme Q-10 or ubiquinone is a vitamin-like body chemical that is vital to the people. In pure form coenzyme Q-10 is an orange-yellow powder without odor and taste. It is partly absorbed from the diet, but also produced in the body itself. Coenzyme Q-10 is responsible in all human cells for the body's production of energy and for protection against external influences. It is found in fish, meat, poultry, nuts, eggs, soy as well as in yeasts. A large part present in the body of the coenzyme Q-10 is from the diet. coenzyme Q-10 GPH capsules coenzyme Q-10 GPH capsules contain 15 mg, 30 mg, 60 mg, 100 mg, 120 mg, 150 mg, 200 mg or 250 mg coenzyme Q-tenth poor nutrition, destroyed Coenzyme Q-10 (for preserved food) as well as disruption of the body's own synthesis (decreased production of age and a lack of various vitamins) can lead Q-10 deficiency to the coenzyme. A daily intake of Coenzyme Q-10 supplements in these cases the diet makes sense. commodity description is only coenzyme Q-10 Kaneka used. Kaneka Q10 is 100% pure, natural possidentes Q-10, which is produced by fermentation. The produced under stringent GMP rules Q-10 Q-10 containing only the trans and is free from synthetic cis-isomers. The raw material meets the European, American and Japanese Pharmacopoeia. KanekaQ10 is safe because it corresponds to endogenous coenzyme Q-10.
It contains no animal feedstock, Kosher certified, BSE and GMO-free and free of allergens. The gelatin used in the hard gelatin capsules, BSE / TSE-tested pharmaceutical gelatin. Suggested use coenzyme Q-10-GPH 15 mg capsules: Adults up to 3 x 2 capsules daily Coenzyme Q-10-GPH 30 mg capsules: Adults up to 3 x 1 capsule day Coenzyme Q-10-BPH 60 mg capsules, coenzyme Q-10 GPH 100 mg capsules, coenzyme Q-10 GPH 150 mg capsules, coenzyme Q-10 GPH 200 mg capsules, coenzyme Q-10 GPH 250 mg capsules : Adults take 1 capsule daily Coenzyme Q-10 GPH liquid capsules: 1-3 times daily 10-30 drops, taking on individual needs information diabetics: contains mannitol