COENZYME Q10: Benefits, Side Effects, Uses, Dosage, Warnings?
Coenzyme Q10 plays a central role in the mitochondria, the so-called "powerhouses of the cell"
There Coenzyme Q10 is an essential component of the respiratory chain. With the help of these respiratory chain, the cell produces energy in the form of ATP, the universal energy unit of our body. ATP provides our organs and muscles with energy, so that they can perform their functions. A substance coenzyme Q10 could replace, does not exist in our body. Coenzyme Q10 is therefore absolutely essential for us. Only with coenzyme Q10, the energy can be converted from our food optimally by the body and used. The power supply is not the only task of Coenzyme Q10:
Coenzyme Q10 is essential for efficient energy production
Coenzyme Q10 contributes to the integrity and stabilization of cell membranes in
Coenzyme Q10 is a potent fat-soluble antioxidant
Coenzyme Q10 protects the cell , z. B. from free radicals
CoQ10 regenerates vitamin E
Coenzyme Q10 strengthens the immune system
Free radicals are an unavoidable by-product of many metabolic processes. Come factors such as smoking, pollution, stress, chronic inflammatory diseases, etc. added, the number of free radicals increases. The problem: Free radicals cause oxidative stress. Thus, free radicals damage eg the membranes of our cells and ultimately our bodies. A free radical induced oxidative stress load each individual cell and thus the whole organism. Meanwhile, oxidative stress is partly responsible for many diseases. They include, for example, Alzheimer's, cancer, Parkinson's disease and coronary heart disease. A highly effective antioxidant protects us coenzyme Q10 from the damaging oxidative effects of these free radicals. What Coenzyme Q10 especially valuable makes: Coenzyme Q10 is right on the education center of many free radicals are available: in the mitochondria. To help coenzyme Q10 to reduce the consequences of increased oxidative stress in the mitochondria. As a fat-soluble substance is Coenzyme Q10 can also move in the cell membrane. It can in particular also to protect the membranes from oxidation and stabilized. It is important to know that cell membranes are comparable up a well-ordered brickwork so completely that no harmful foreign molecules can intrude into the cell. Free radicals, but also many fat-soluble E-waste from the food can interfere with the protective function of the cell membrane integrity. . Protection against oxidation is therefore an important function, because intact cell membranes are essential for the proper conduct of the intracellular metabolic processes to the organs that contain according to their high energy conversion particularly much coenzyme Q10, include:
A deficiency of coenzyme Q10 affects the energy balance of cells
This is especially organs that require Q10 analogous to their high energy conversion much coenzyme. Accordingly, a good supply of coenzyme Q10 prerequisite for physiological energy (ATP) supply to the muscle cells and organs as well as the performance of the heart and the brain. Coenzyme Q10 is not only as a dietary supplement, but also in cosmetics used. As part of creams coenzyme Q10 to the age-related decline of coenzyme Q10 balance in the cell membranes of the skin and reduce harmful free radicals in the skin. So should coenzyme Q10 excessive skin aging prevention.
Coenzyme Q10 (Ubiquinone)
Name: Coenzyme Q10, ubiquinone, coenzyme Q, CoQ10, Eng. Ubiquinone affiliation: benzoquinone derivative with isoprenoid side chain, coenzyme dose range for average food intake: 3-10 mg depending on diet and according to several studies (9-11) occurrence in foods: beef, fish, chicken, soy oil, peanuts, sesame seeds, pistachios dose prevention and therapy: 50-100 mg daily for prevention, 200-300 mg daily and more for the treatment of heart disease and other diseases side effects: In normal doses no side effects are known. A large overdose (more than 1000 mg) may include abdominal pain, digestive problems and flu symptoms are observed.
Coenzyme Q10 is a representative of ubiquinones, they can be synthesized by humans and animals. Therefore, coenzyme Q10 is not considered essential vitamin (1). Coenzyme Q is a fat-soluble molecule that as an antioxidant and in the energy metabolism of mitochondria plays an important role, by transferring electrons, which thus serve as an energy carrier of metabolic products of food and fat reserves on the body's energy currency ATP (adenosine triphosphate). It is found everywhere in living organisms and is chemically a benzoquinone with a longer carbon chain (isoprene units from each 5 carbon atoms), whose length can vary from organism to organism, and consists in humans of 10 isoprene units, hence the name coenzyme Q10 in man (2).
The current research shows the following effects of supplementation with coenzyme Q10:
1 Can a treat heart failure and the pumping capacity of the heart, left ventricular ejection fraction measured in (LVD), increase
the second Reduces the degree of oxidative stress (by decreasing oxygen free radicals)
third Prevents a decrease in oxygen consumption and mitochondrial energy production, which can be commonly observed in old age and also in diabetes
fourth Increased mitochondrial energy levels
5th Increases glutathione and vitamin C levels, which in the whole body antioxidant protection from free radicals
6th Can be useful for the control of diabetes
seventh Promotes energy production from fat and sugar in the mitochondria
8th Increases the breakdown of blood sugar
9th Reduces a vordiabetische insulin resistance
10th Improved some biomarkers of metabolic activity
Oral ingestion of coenzyme Q10 increases the Q10 levels in blood plasma, lipoprotein and blood vessels. Whether this also the concentrations of Q10 are increased in tissues is unclear, especially for healthy people without deficiency. Supplementation with coenzyme Q10 could achieve clinical and metabolic parameters in some patients with hereditary disorders of the mitochondria.
Coenzyme Q10 (ubiquinone 50)
Coenzyme Q10 (ubiquinone 50) is involved in the oxygen absorption of the cells and their production of energy. At the same time Coenzyme Q10 has the task to trap free radicals in the body, or to prevent their formation. Ubiquinones hot these substances because they can be synthesized in principle by all living cells (Latin ubique everywhere =).
As vitamin can not be called Q10, already more than a nutrient. Q10 is not a substance that must be supplied from outside, because the body can produce them in sufficient quantities themselves. It is also not to small amounts that stimulate action. The body is relatively large amounts of coenzyme Q10.
Has not yet been demonstrated for coenzyme Q10, that the supply of this material as a dietary supplement has a significant positive effect on the function of the human body. [Lit-1]
The advertising claims "increase the performance and health" and "strengthening the immune system" for coenzyme Q10 have been scientifically confirmed.
Coenzyme Q10: demand, shortages, oversupply
Deficiency of coenzyme Q10 are as yet not known. Perhaps the body's production of coenzyme Q10 is reduced but if the supply of other nutrients and vitamins is bad.
"Hazard potential: Possible side effects of the administration of coenzyme Q10 in doses between 50 and 300 mg per day in clinical trials on humans in most cases several weeks of use gastrointestinal intolerance as loss of appetite, nausea, diarrhea, or general malaise were observed in the upper dosage range and increase the plasma enzyme levels of lactate dehydrogenase or glutamate oxaloacetate transaminase (Baggio et al, 1993;.. Lampertico et al, 1993). In a study of healthy athletes who received either 120 mg of coenzyme Q10 or placebo (a dummy treatment) became apparent after several days of intensive training increased activity of plasma creatine kinase in the Q10 group, which can be interpreted as an indication of cell damage (Malm, 1996). Possibly induced coenzyme Q10 in high doses the formation of free radicals that for lipid oxidation and damage to cell membranes can lead (Demopoulous et al., 1986). "[Lit-1]