COENZYME Q10: Benefits, Side Effects, Uses, Dosage, Warnings?
Coenzyme Q10 is a fat soluble substance that can be produced by the human body itself and is therefore not counted among the vitamins. Coenzyme Q10 belongs to the group of so-called 'ubiquinone', which - as the name says - ubiquitous (everywhere) are present in living organisms. It can also be supplied through the diet.
Coenzyme Q10 is used primarily in the energy powerhouses of the cells, the " mitochondria ", before. Therefore, the highest Q10 levels were found in the organs with the highest energy requirements such as the heart and liver.
An adequate intake of coenzyme Q10 (ubiquinone) is important because this substance supports the body in maintaining the following key features:
Conversion of carbohydrates and fats into a usable form of energy by the cells
Protection of cells, tissues and organs from the damaging effects of free radicals ( antioxidant function), which accelerate the aging process and contribute to the development of numerous health problems such as heart disease and cancer can.
Reduction of disease risk
as antioxidant Coenzyme Q10 neutralizes harmful free radicals , which play a role in the aging process. Various factors (such as the aging process and stress) may contribute to the coenzyme Q10 content decreases in the body and reduce the stress resistance and regenerative capacity of cells. In general, the coenzyme Q10 content in the body decreases with age.
In the context of animal experiments, it was found that rodents that coenzyme Q10 was supplied as a dietary supplement, lived longer than their peers who were not treated additionally with coenzyme Q10. It is not yet known whether and how supplementation with coenzyme Q10 effect on the life of the people.
a symptom of many diseases of the heart and blood vessels, the hardening of the arteries are: fatty substances such as cholesterol are deposited in the blood vessels, causing a thickening and narrowing of the arteries walls. As antioxidant coenzyme Q10, the damaging effects on the development of hardening of the arteries contribute, may inhibit.
By the use of Coenzyme Q10 in the prevention of arteriosclerosis promising results have already been achieved. However, further studies are needed to deal with the specific role of Coenzyme Q10 in the context of disease risk reduction *.
- See also Principles - The complexity of micronutrient research
Any dietary or drug treatment with high doses of micronutrients should be done only under medical supervision.
Hereditary mitochondrial disorders
through supplementation with coenzyme Q10 could function with inherited abnormalities of the energy production in people with mitochondrial positive effects. In patients suffering from a rare genetic defect with respect to the endogenous coenzyme Q10 production, the supply of Coenzyme Q10 was able to lead to marked improvements.
research results indicate that the positive effect of coenzyme Q10 in the prevention and treatment of heart diseases, particularly in its role as an antioxidant is due.
In a clinical study , it was found that persons who coenzyme Q10 was administered within three days after a heart attack every day, much less likely to result infarction and chest pain suffered as patients who did not receive coenzyme Q10. In addition to the members of the first group there was a lower risk of dying from heart disease.
People with congestive heart failure have low coenzyme Q10 levels. This disease occurs when the heart is unable to pump blood efficiently, which can lead to accumulation of blood in other parts of the body (such as the lungs and legs).
Various studies have come to the conclusion that taking coenzyme Q10 preparations in these patients leads to a decrease in swelling in the legs, improves breathing by reducing fluid in the lungs and increased exercise tolerance; In other studies, such effects could not be obtained *.
The results of some clinical studies with a small number of subjects suggest a blood pressure lowering effect of coenzyme Q10.
There are other, larger-scale studies required to determine the effect of coenzyme Q10 in the treatment of high blood pressure to assess ('hypertension') * better.
Elevated cholesterol levels
people with elevated cholesterol levels have, in comparison to age-matched healthy individuals on rather lower coenzyme Q10 levels. So-called 'statins' - - to reduce the natural coenzyme Q10 content in the body In addition, some cholesterol-lowering drugs appear.
It was shown that this deficiency can be remedied by taking coenzyme Q10 supplements, without affecting the desired positive effects of statins on the cholesterol levels are affected.
has been shown that by the supply of coenzyme Q10 before heart surgery, including bypass surgery and heart transplantation, the extent of the damage by In clinical studies, free radicals decreased, strengthen heart function and the occurrence of irregular heartbeat ("arrhythmias") during the recovery phase can be reduced.
high blood pressure , elevated cholesterol levels and heart disease are symptoms that commonly associated with diabetes occur. Research results indicate that taking coenzyme Q10 supplements to improve heart health and blood sugar levels and positively in the treatment of elevated cholesterol levels and high blood pressure could impact in diabetics.
Was demonstrated in two clinical studies that coenzyme Q10 in diabetic patients not (as often assumed) to a sudden and severe drop in blood sugar levels ("hypoglycemia") leads. It was concluded that diabetics in the treatment of cardiovascular disease can take coenzyme Q10 supplements without hesitation.
In Parkinson play the decreased activity of elements of the energy production in the mitochondria are involved, and increased oxidative stress in a particular region of the brain involved. As part of the energy extraction process and in its function as an antioxidant , the use of coenzyme Q10 in the treatment of Parkinson's disease, therefore, could prove useful.
In a study of patients with early stage Parkinson's disease has been found that the brain function in patients undergoing coenzyme Q10 were administered -Präparate, compared to patients who received placebo, slowly deteriorated. These results are promising, but larger-scale studies are needed to confirm it *.
Individual case reports suggest that in addition to conventional treatment of breast cancer patients had positive effects can be achieved by supplementation with coenzyme Q10. However, since not enough relevant controlled clinical studies were conducted, is still too little about the use of coenzyme Q10 in cancer treatment known *.
Periodontal disease is a common problem that is associated with swelling, bleeding, pain and redness of the gums. A lower coenzyme Q10 content in the gums of people with gum disease has been demonstrated in clinical studies.
In some clinical studies with small numbers subjects could be achieved by supplementation with coenzyme Q10 faster healing results and a faster tissue regeneration.
To clarify, what use is the supply of coenzyme Q10 in addition to conventional treatment of periodontal disease, further studies need to be performed.
Clinical preliminary studies suggest that. due to the supply of Coenzyme Q10 and physical performance, as a component of cosmetics, the skin could be improved In addition, strengthening the immune function in individuals with immune deficiencies such as AIDS and improve the symptoms of tinnitus have been described.
- See also Principles - The complexity of micronutrient research
So far, no specific recommended intake for coenzyme Q10 were published by the health authorities.
Some experts recommend a daily dose of 30-200 mg for adults over 19 years.
Since CoQ10 is fat soluble, it should be taken with a fat-containing meal to ensure optimal absorption in the body.
In several European countries the average daily coenzyme Q10 intake estimated from food to about 10 mg.
It is assumed that an adequate supply is ensured with coenzyme Q10 by the body's own production and a varied diet in healthy people.
In people with diabetes , cancer and congestive heart failure as well as in individuals taking lipid-lowering medications (see Security), however, are often still low coenzyme Q10 levels in the blood.
There are no reports of symptoms of coenzyme Q10 deficiency in the general population.
Oily fish (eg. Example salmon and tuna), organ meats (eg., Liver), and whole grains are considered the best coenzyme Q10 sources.
So far, no significant side effects of coenzyme Q10 addition of up to 1,200 mg / day, are known.
Some people can Q10 after taking high doses of coenzyme gastrointestinal complaints (eg., nausea, diarrhea, loss of appetite and heartburn) occur.
Since no controlled safety studies in pregnant and lactating women have been performed so far, no statement about the intake of coenzyme Q10 preparations in these groups can be made.
Since the possibility of an interaction is, should be obtained before a simultaneous intake of dietary supplements and medications Council by qualified medical personnel.
in Part 1 of my BLOGs I became involved with the most important properties, the synthesis, the occurrence in food and the various forms of coenzyme Q10.
Coenzyme Q10 - The Power enzyme - Part 1
Today it is to go to benefits arising from a proven supplementation with coenzyme Q10. You will be surprised how versatile coenzyme Q10 can be applied and is also already applied.
Finally, I would like to give a lot to the side effects and possible dosages of coenzyme Q10 supplementation on the way.
I hope you enjoy my designs!
Benefits of supplementation with coenzyme Q10
In the following section I will show you examples in which persons supplementation with coenzyme Q10 could provide significant advantages for different situations. You will see that it is not just about the health area in coenzyme Q10.
Heart Health and Coenzyme Q10
Since the advent of greatly reduced CoQ10 in heart muscle with age, it is already successfully used in coronary heart disease, hypertension and heart failure. In 75% of all people with a heart condition it possible to determine a coenzyme Q10 deficiency.
Study data on heart failure
A study of SA Mortensen was able to prove that a dose of 100 mg coenzyme Q10 per day after 4 weeks resulted in significant improvements in heart failure patients.
Dr.WVJudy et. al. compared the clinical course of critically ill heart patients even with conventional medical therapy, a placebo or with the use of coenzyme Q10. After 5 years, all subjects had died in the placebo group, whereas only 50% of coenzyme Q10 patients were still alive. Even after 8 years were still 36% of coenzyme Q10 subjects.
In a large-scale study of the influence of 50-150mg Coenzyme Q10 on 2664 heart failure patients was investigated. After 3 months of taking ALL recorded positive changes concerning the heart. In the patients and changes in muscle and organ functions were found. Taking a holistic made to improve the quality of life.
Heart failure, and coenzyme Q 10
Presentation: Q 10 and heart failure
Studies of hypertensive heart disease
In hypertensive patients (sudden sharp rise in blood pressure) a significant reduction in heart rate and the systholischen and diastolic blood pressure was achieved with 120 mg coenzyme Q10 for 8 weeks.
Studies on heart attack
With 120mg of coenzyme Q10 could be reduced in acute myocardial infarction patients cases of angina pectoris, Arrythmen of the heart and other cardiac events.
RB Singh et.al. from the Medic. & Research Hospital in Moradabad was with 120mg Coenzyme demonstrate a decline in new infarcts, Arrythmen of the heart or angina pectoris Q10 for 6 weeks at 144 heart attack patients.
Studies of general heart health
Prof. K. Folkers et.al presented in the subjects of his study with the use of Coenzyme Q10 100mg / day, an improvement of markers fixed suggestive of heart health and cardiac output.
Coenzyme Q10 and Heart Health
Presentation: Q 10 and heart health
In connection with the use of ACE inhibitors, the use of coenzyme Q10 is still clearly to be clarified.
For the heart CoenzymQ10 is a very important substance. Not in vain there is a large amount saved it. Who is considered "risk candidate" for deficiencies in CoenzymQ10, should consider additional resource to consider.
Weight control and coenzyme Q10
Coenzyme Q10 can make a decisive contribution to the weight reduction and weight management.
In a study by Van Gaal subjects were divided into 2 groups. Group 1 had a low coenzyme Q10 levels, group 2 was adequately supplied with coenzyme Q10. Both groups had a mean age of 37 years and were daily administered 100mg Coenzyme Q10.
As a result, turned in subjects from group 2, a significant weight loss of 16,4kg in 3 months. Group 1 could nevertheless experienced a weight loss of 5.8kg. This represents an increase of 12.2% and 5.4% respectively. Similar changes, namely 12.3% and 5.4%, were found also in BMI.
For the project to reduce weight, it might be advantageous to have knowledge of its supply of coenzyme Q10 and possibly which to supplement.
Sports Performance and coenzyme Q10
Sport, free radicals and oxidative damage
Sport is healthy! I think of this theory there is nothing to shake, and I would always make a distinction between personal health, Breitem-, and competitive sports.
Especially with intensive long endurance loads occur due to the immensely higher oxygen turnover as well as more oxygen radicals. This can induce oxidative damage to body cells. As we have already seen, coenzyme Q10 acts exactly at the place of production of free radicals as a scavenger. It is therefore obvious that the consumption of coenzyme Q10 increases in such a situation and you should strive to ensure a high volume of coenzyme Q10 to here to say free radicals to fight.
Coenzyme Q10 protects particularly during intensive long endurance against oxidative damage.
Study: improved performance and coenzyme Q10
The scientists Folkers, Littaru, goat and Enzmann investigated the effects of coenzyme Q10 supplementation of 180mg / day in competitive athletes on the blood levels of coenzyme Q10, as well as the performance in submaximal and maximal area.
The result was expected to be detected with higher supplementation of coenzyme Q10 blood levels in the test group. In a placebo group, these increases did not materialize. Also presented in the test group in the affected areas load a performance increase of up to 30% a.
Coenzyme Q10 has ergogenic potential!
Study - Antioxidative Stress and performance in swimming
A study from the "Open Sports Medicine Journal" dealt with the effects of coenzyme Q10 supplementation on oxidative stress and performance. To this end obtained young swimmers over 22 days 300mg Coenzyme Q10. Were measured blood parameters in coenzyme Q10 and some stress markers. Next performance test, the times of short and long floating units in conjunction with a supplementation also were compared.
With 300mg of coenzyme Q10 for 22 days could regarding significant improvements. Fatigue, physical maximum load and short floating units can be achieved. Overall, showed taking increased CoQ10 blood levels and thus to a reduced volume of stress markers such as NOx, Proteinhyperoxid or malondialdehyde and an increase in Glutahion. *
- Glutahion is a sulfur-containing protein substance . He is present in every cell of the body and represents a tremendous support for the immune system.
Coenzyme Q 10 immune markers
Presentation: immune markers
Performance improvement Q10
Representation: performance climbing achievements by coenzyme Q10
With coenzyme Q10 can reduce stress and improve performance
Further observations to ubiquinol in Sports
In women's football, there is an interesting report in connection with ubiquinol. The Japanese team could decide the 2011 world championship. Japan was the only team that began the dietary supplement ubiquinol not only the tournament but already in the preparation (over 2 years). Striking were the physical and mental strength and endurance of the players. They could easily prevail against the partially physically superior competitors. The supplementation with ubiquinol is at least attributed to a portion of these abnormalities.
Even with Japanese Kendo fighters were registered with the inclusion of Unichinol 300mg / day, significant increases in exercise performance. Sometimes caused ubiquinol for protecting muscles from injury and shorten recovery times.
Ubiquinol involves both health and performance enhancing potential and is therefore already in use in many countries and sports as a performance-enhancing supplement.
Other effects of coenzyme Q10
In an 8-week study in hypertensive patients was taking 120mg of CoenzymQ10 / day an improvement in blood pressure, while triglyceride levels, the glucose levels are observed and, consequently, the insulin levels.
Initial studies suggest an analgesic, agility improving effect on rheumatism out.
Even with lung disease or inflammation of the pancreas Coenzyme Q10 could improve the symptoms
Not anonymous, the effect of coenzyme Q10 against cancer, chemotherapy side effects and tumor growth remain.
A kind of "aging effect" occurs in association with the use of coenzyme Q10 as it in the mitochondria prevents age-related degeneration and mutations and thus maintains the functionality of our cells. The aging of the skin and formation of wrinkles can weaken with sufficient coenzyme Q10. This is one reason why many skin creams are enriched with coenzyme Q10.
In persons with chronic fatigue syndrome was observed in studies that the blood volume decreases of coenzyme Q10 during the day. With 100 mg / day, an improvement of symptoms was achieved in 60% of subjects aged 28-38 years. With 300 mg / day, presented an improvement in 91%.
Even people with migraine have already benefited from taking 3x100mg Coenzyme Q10 / day in studies by migraine attacks decreased from 4.4 to 3.2 per month.
The span of the positive effects of coenzyme Q10 is enormous, ranging from health to sports and, ultimately, in the therapeutic range.
Doses in coenzyme Q10
Some doses have already been called to the respective requirements in the previous studies. From a therapeutic perspective, a daily dosage from 100mg is considered effective. When heart problems / day be used up to 300mg (400mg even in some cases)
To take into account valid for coenzyme Q10 that both are subject to the endogenous synthesis and utilization of food supplements a strong individuality. In case of doubt, the current status can be determined through a blood test.
Also, it is important to remember that the body's reserves, as already mentioned, starting from the age of 20 about to sink.
From a health perspective, the intake of 100 mg / day may be recommended. For increased requirements such as disease or in athletes daily doses of up to 300 mg / day are desirable. By Prof. Sinatra from the USA you know, for example, that he administered his patients with heart failure between 240 and 360 mg coenzyme Q10. Various diseases are even treated with up to 720mg / day.
Since ubiquinol promises a much higher bioavailability, faster absorption and longer efficacy, dosages may fail here correspondingly lower.
In conjunction with D-ribose is synergetic effects seem set.
With coenzyme Q10 no rapid energy boost but a natural long-lasting increase in energy levels is expected. Be positive changes are generally set clear, the worse the supply situation with coenzyme Q10. From about 5 days of taking can enter positive changes.
Coenzyme Q10 at the proper dosage depends on several factors. In general, going from an overdose of no danger, whereas others can fail any improvements at a lower dosage.
Side effects with coenzyme Q10
With the intake of coenzyme Q10 as a dietary supplement , there is no information on possible side effects even if it is taken for several years. A study of Shuts et al in Parkinson's patients could find themselves with the raising of 2400mg / day no side effects. Other studies report a symptom-free income to 600mg / day.
CoenzymQ10 and drugs
When taking certain medications, the additional administration of coenzyme Q10 promises even a derating of side effects. eg timolol, a receptor blocker which is used in cataract. As a side effect of a possible heart failure is called. Studies show that the administration of 90 mg coenzyme Q10 / day significantly reduces the risk of this side effect. Even with chemotherapy and the onset of this decreased mitochondrial respiration can Coenzyme Q10 provide good services.
Coenzyme Q10 is free of side effects and can even help to reduce side effects of certain medications.
In my remarks to coenzyme Q10 has been found that this is a very interesting substance with versatile application. Particularly of interest is shown CoenzymQ10 for older people, people with certain diseases, for athletes, smokers and some other vulnerable groups. With them is either assumed a poorer uptake and conversion or higher required.
I have reported in part 2 comprising about what positive impact brings a coenzyme Q10 supplementation with it. Especially often it is used in diseases of the heart.
From a sporting point of view one benefits of coenzyme Q10 for one of its strong antioxidant activity as well as about his performance-enhancing effect. Also, to reduce weight, a taking has already proven supportive as well as many other objectives.
To conclude that coenzyme Q10 is actually a power-enzyme. Many do not see the forest for the trees and overlook the issue of performance-enhancing substances, the small natural helpers. I hope I can show my BLOG many readers a new alternative that is value that you once embarking on it.