COENZYME Q10: Benefits, Side Effects, Uses, Dosage, Warnings?
Coenzyme Q10 is a vitamin-like substance, which was discovered at the University of Wisconsin until 1957. Q10 is both produced by the body itself, as well as absorbed through food. However, some manufacturers offer food supplements, creams and lotions with extra servings of coenzyme Q10.
However, experts call these extra servings than useless.
What is the effect of coenzyme Q10? Existence of side effects? As there is a lack of Q10?
Occurrence and effects of coenzyme Q10
The human body uses every day to relatively large amounts of coenzyme Q10. However, since it also manufactures the coenzyme itself, there is rarely a shortage. In addition, the substance is absorbed through the food - corn , sardines, soybean, nuts , meat, poultry , and some vegetable oils are particularly extends to the coenzyme.
In the body, Q10 is used as a component of the mitochondria, where the inhaled oxygen is consumed and energy is obtained from food. Even in the defense against oxidative stress this coenzyme plays an important role, since it captures free radicals. Therefore, it is rumored Q10 a firming and health benefits.
Coenzyme Q10: deficiency and side effects
A deficiency of coenzyme Q10 comes with a normal diet rarely occurs. However, the content of coenzyme decreases in the organs occasionally with age. This can lead to high blood pressure , heart muscle disorders, heart failure and atherosclerosis lead. Whether an additional administration of Q10 can help here, however, is not yet clearly established.
In any case, the side effects should be considered when taking coenzyme Q10 capsules. In compliance with the regular daily dose of ten to a maximum of 30 mg daily there are no objections. In higher doses, it may cause the following side effects of Q10:
In addition, patients taking the anticoagulant medication, dispense with Q10 as a dietary supplement.
Capsules and cream with coenzyme Q10
With "health benefits" and "strengthening the defenses" advertise the manufacturer of Q10 preparations. As a dietary supplement coenzyme Q10 is often sold in capsule form. In addition to anti-aging creams and body lotions with Q10 tighten the skin and give it a more youthful appearance.
The effect of these preparations, however, was refuted by the Federal Institute for Consumer Health Protection and Veterinary Medicine (bgvv). An in-depth investigation came to the conclusion that taking the dietary supplement was not indeed harmful, but could also "no evidence of any significant positive effects on the function of the human body".
In a study of anti-aging creams also Stiftung Warentest certified products only "microscopic successes". Instead of relying on chemical preparations, consumers should therefore pay more attention to a healthy lifestyle and a balanced diet to feel healthy and young long.
The coenzyme Q10, the use of which was seen by many cardiologists been skeptical has halved in a randomized double-blind study, the mortality rate of patients with severe heart failure (NYHA III / IV). At the symposium Heart Failure 2013 in Lisbon, where the as yet unpublished results were presented, was against a premature use of antioxidant vitamin, which is marketed as a dietary supplement, warned.
Coenzyme Q10, also known as ubiquinone or Q10, was first discovered in the cardiac muscle of cattle in 1957. Its chemical structure was elucidated by Karl Folkers in 1957. Q10 is a coenzyme involved in energy production in the mitochondria, which explains the high concentration in the heart muscle.
Folkers 1985 could show Svend Aage Mortensen together with the Heart Center of the University Hospital in Copenhagen based on heart biopsies that the concentration of Q10 decreases in the tissue with the severity of heart failure. Mortensen explains this with a "steal effect", in which the antioxidant properties of Q10 may be used for purposes other than the production of energy in the mitochondria. Adds that many patients are treated with heart failure with statins, which could reduce the concentration of Q10 by up to 40 percent.
In recent years, an attempt was made in about 15 clinical studies to support the cardiac output in patients with severe heart failure by administering Q10 - usually with meager results. A recent meta-analysis of Domnica Fotino from Tulane University in New Orleans, the left ventricular ejection fraction was barely increased by 3.67 percent. However, there were small studies (total of only 395 patients) and had no statistical size to investigate a reduction in mortality.
on the topic
Abstract of the study
Press release of the European Society of Cardiology
Study in PNAS in 1985
This was the first time in the "Q-Symbio" study of the case, the total of 420 patients (ie more than all 13 previous studies) with heart failure of NYHA class III or IV included. The patients were treated at 17 centers in Denmark and eight other countries (no German participation) with Q10 or placebo. The primary endpoint was the time to occurrence of severe cardiovascular complications (unplanned hospitalization, cardiovascular death, heart transplantation or mechanical circulatory support system).
As Mortensen tells now, the primary endpoint (14 percent) occurred in the first two years of treatment with Q10 treatment in 29 patients only half as likely to placebo with 55 patients (25 percent). The overall mortality was almost halved with 9 percent (18 patients) versus 17 percent (38 patients) in the placebo arm.
Also in cardiovascular mortality and the number of hospitalizations due to heart failure, the advantage was significant. According to Mortensen is Q10 for more than ten years and since ACE inhibitors and beta-blockers the first drug for which a mortality-lowering effect in heart failure could be detected.
Q10 remained in the studies without significant side effects (the publication is still pending) and as a dietary supplement is available without a prescription. Mortensen warned the patient but before the temptation of self-medication, since Q10 drug interactions could have.
That coenzyme Q10 - CoQ10 or short - the heart healthy obtains a natural way and even can make a sick heart healthy again, is known. But there is more positive news about CoQ10, which are explained here.
But first, a new study from Cairo. This CoQ10 showed a surprising effect: It freed from depression and anxiety. The study was conducted on animals, in this case, in rats, carried out. Why a known safe supplements can not be studied in people with depression, instead of torturing rats, so they developed a depression and anxiety remains a mystery. But at least it was the animals thanks coenzyme Q10 then better again.
After the animals by forced swimming and chronic stress ("CRS" after the English "chronic restraint stress") were put under stress - so do something else but sometimes cruel children - artificially anxiety and depression were generated in them, as in laboratory tests usual. Then we fed them for three weeks with high doses of CoQ10.
Use of background data from other studies in which a reduced hippocampus and increased oxidative stress in hippocampal cells have been associated with depression, the researchers focused in this study on the biochemical events in this brain region and observed the behavior of the animals.
The hippocampus is a small part of the gray matter of the brain responsible for emotional response and memory formation. It has the shape of a sea horse, sitting on either side of the lower part of the brain. It is believed that this region is involved in Alzheimer's disease as the first.
It was found that the observed anxiety and depression during feeding of CoQ10 largely disappeared. The biological markers showed a higher antioxidant activity in the hippocampus, an indication for the repair of oxidative damage to cells and DNA.
The work performed at the National Center for Biotechnology ( NCBI was published), was published on 11 January 2013 on the website PubMed.org . The headline read: "Coenzyme Q10 shows antidepressant-like effect, reducing oxidative / nitrosating DNA damage in the hippocampus in rats dauergestressten".
The conclusion provides a paradoxical element: "... It is conceivable that CoQ10 in controlling depressive disorders show a therapeutic effect. Nevertheless, before the safe use in humans further investigations are necessary to describe the mechanism of antidepressant action of CoQ10 in more detail and to substantiate the results. "
The paradox lies in the phrase italicized. It's ok, Selective serotonin reuptake inhibitors (SSRIs) such as Prozac, Zoloft, Paxil and other open and everywhere prescribe, although they aggravate the disease often enough - up to a psychosis or suicidal or homicidal impulses.
CoQ10, however, shows only positive side effects for the health.
What CoQ10 Ubiquinol or else we can do for you
Ubiquinol is a more expensive and rarely used form of coenzyme Q10. About 40-year-olds is often recommended to take better Ubiquinol. This is to a reduced or non-oxidized form of CoQ10. Normal CoQ10 supplements are not reduced. You are oxidized.
So the body must convert only in the lighter recorded reduced (non-oxidized) Ubiquinol the (oxidized) ubiquinone CoQ10, and that is with increasing age more difficult. So if you already have a few more years of life under his belt, it is advisable for reduced CoQ10, ubiquinol So, spend a little more money.
CoQ10 is an enzyme which is normally produced in the liver. This production must be brought under certain circumstances by a supplement in transition, given our stressful and polluted environment.
Coenzyme Q10 is a super antioxidant, it enhances the cell metabolism, in particular the activity of mitochondria in the cells. If this weakens, signs may develop premature aging, but also all kinds of autoimmune diseases, neurological disorders and heart disease. Non-synthetic vitamin E works very well with CoQ10.
In Japan, the cardiologists prescribe their patients mostly CoQ10, often instead of statins or other medications. So you had some excellent results. Many consider Coenzyme Q10 as an anti-aging supplement. And apparently it also helps with anxiety and depression.