Coenzyme Q10: Benefits, Side Effects, Uses, Dosage, Warnings?


COENZYME Q10: Benefits, Side Effects, Uses, Dosage, Warnings?

Effect of coenzyme Q10
At what disease Co-enzyme Q10 acts?
As an energy supplier, while antioxidant that is present in all our body cells, the co-enzyme Q10 increases obviously a crucial role in maintaining the health of our entire body and also in the prevention and treatment of diseases! The following conditions result in an acute Q10 deficiency, which should be as balanced as possible, to enable the fastest possible recovery and prevent permanent damage!

These include the following diseases:
Age-related complaints
Angina pectoris
Compensate for the side effects of blood lipid-lowering drugs: HMG CoA reductase inhibitors
Autoimmune diseases
Chronic Fatigue Syndrome
Chronic poisoning
Churg-Strauss syndrome
Ulcerative Colitis
Crohn's disease
Bowel disease
Diabetes Mellitus
Skin diseases
Heart disease (coronary heart disease, heart attack, atherosclerosis, heart failure heart rhythm disorders, prevention), supplement with drug therapy, here also helps gotu kola- very good
Down syndrome
Mucous membrane disorders
Various inflammations
Goodpasture's syndrome
Brain edema
Brain trauma
Hormone disorders
Pulmonary fibrosis
Lyme Disease
Stomach Diseases
Multiple sclerosis (MS)
Myocarditis (nichtbakteriell)
Kidney disease
Rheumatoid Arthritis
Schoenlein-Henoch syndrome
Shock states
Sjögren's syndrome
Mitochondrial defect
Generic. Muscle weakness
Spontaneous abortion
Metabolic diseases
Parkinson's disease
Systemic Erytomatodes
Toxic brain damage
Toxic environmental diseases
Werner Syndrome
Wegener's granulomatosis
Cystic fibrosis
Diabetes / diabetes (prevention of late complications, improve blood pressure and blood sugar levels)
Furthermore, recent research have indicated that under an additional dose of Q10 certain medications can be dosed down because Q10 increases the positive effect of these drugs (be sure to consult with the attending physician).

Q10 may further demonstrably reduce the negative side effects of certain drugs, such as some chemotherapy drugs, cholesterol-lowering agents and beta-blockers! Unfortunately, many drugs enhance cell oxidation, here you should with Antioxidanzen as Q10, vitamin C, OPC counteract this damaging process! (Also, grapefruit seed extract is an antioxidant!)

Additional Q10-taking is also particularly indicated for:

unilateral or limited diet with diets, fasting, etc., as resulting malnutrition to Q10 deficiency leads and thus performance estate and susceptibility to diseases!
Athletes must be replenished especially in power and endurance athletes, since extremely much Q10 is consumed during training and competition for the muscular and cardiac work and one of us! So it is not surprising that American Olympians are supplied by default with Q10! Furthermore, the increased oxygen uptake in the body of the athlete reinforced produces free radicals that attack the cells - here must be very conscious recourse to Antioxidanzen as Q10, OPC, vitamin C, to prevent this damaging mechanism!
Alcoholism damages the liver and the heart, here you can take the Q10 detoxification processes and help these organs to regenerate!
Patients receiving chemotherapy, because many chemotherapy damage the heart and limit the cardiac output - Q10 may counteract here and regenerate the damage!
People who are having heart surgery, here compensated Q10 at reperfusion of the heart damage!

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Q 10 against depression
Much like "Vitamin C" and "OPC", both of which reduce the penetration of the blood brain barrier and optimization of calcium turnover depression, Q10 proves to be a 3rd partner very helpful in which it enhances cell-to-cell communication of neurons. This completely free of side effects, while the classical antidepressants have side effects, the bishin of dangerous blood pressure lowering over cardiovascular disorders to fatal cardiac arrhythmias! Moreover, the said side effects with additional Q10 gifts can be mitigated!

Q10 helps with rheumatic disease
Rheumatism is usually activated with osteoarthritis and arthritis assoziert, but is the generic term for over 400 diseases. In pilot studies in 70 patients with rheumatoid arthritis have Dr.F. Enzmann et al. Found in 1992 that in 60-80% of patients taking Q10 for damping of rheumatic pain and improved mobility led!

Q10 against Chronic Fatigue Syndrome (Chronic Fatigue Syndrome)
In a three month study of 10 women aged 28-38 years, suffering from chronic fatigue syndrome, Judy et al could find that the administration of 100mg of Co-enzyme Q10 / day achieved a significant improvement!

The Q10 levels were lowest before the study in all subjects by 8 clock in the morning and lowest at 17 clock. Bearing exercises led to leg cramps and shortness of breath. These symptoms have been greatly improved after two weeks Q10 intake, blood discharge at night was significantly improved by 1,13min exercises could be performed without cramps and shortness of breath! * 9

In another study presented Judy et al. found that in the first group (A), the Q10 100mg / day received 60% of the patients positive for the coenzyme Q10 therapy responded, while in the second group (B) received 300mg Q10 / day 91% responded positively. The complaints improved with increasing dose, the effect occurred in group B after 30 days in group A after 60 days! * 10

Another indication that the effect of Q10 dose-dependent fails!

Co-enzyme Q10 in lung diseases
According to a study by Fujimoto et al in patients with chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis, these patients have a lowered Q10 levels. The patients suffer from respiratory problems, among others, and heavy legs. After an intake of 90mg per day, the Q10 Q10 plasma levels and exercise capacity of patients normalized increased significantly! * 11

Co-enzyme Q10 compared pancreatitis (Bauspeicheldrüsenentzündung)
As the pharmacist-Journal reported in Issue 9/93, was the death of the tissue are limited to <30% of the total body with a Q10 prophylaxis in 173 of 178 patients, so that surgical operations and intensive therapies could be avoided!

Q10 in alcoholic hepatitis
As the pharmacist-Journal reported in Issue 9/93, the mortality rate of cirrhotic patients with hepatitis was in the antioxidant group, only 6.5% while the control group (without Q10 and others) was 40%. Furthermore, the values ​​for MDA, ammonia, and bilirubin were significantly better than in the control group, so that the duration of the hospital could be reduced by 6!

Q10 problems during menopause (menopause)
One lady caught it already with 35, another with only 60 - menopause with all its unpleasant manifestations in the form of hot flashes, depression, insomnia, headaches, fatigue symptoms, osteoporosis, etc.

Approximately 25% of these women are instructed to seek medical help!

It is known that even in women in menopause usually the Q10 levels are low, doctors and health practitioners on the other hand reported success bishin for complete freedom from symptoms when using Q10 (about 120mg / day)!

Q10 against eczema
As we have already seen, Q10 plays in protection for the skin and is the most important role in the skin due to its uses as a first protective substance!

Eczema is attributed to malfunction of the immune system, the immune system is misdirected and fought substances that are not enemies! The conventional medical response is insufficient in the form of drugs with severe side effects before! As Q10 greatly stabilizes the immune system and improves the cell membrane communication, it should not be missed as adjunctive therapy for eczema!

Q10 helps in the fight against cancer
As we have already learned a Q10 deficiency in diseases suggests quite strongly suggests that the body uses the Q10 reinforced, ergo needs for his recovery!

It will create the balancing be here from the outside by taking Co-enzyme Q10 capsules as soon as possible The more a disease favors the Q10 deficiency, the more important!

In a study by Folkers et al. in 83 cancer patients with 8 different cancers turned out that for all a strong Q10-deficit prevailed, particularly in breast and lung cancer patients!

This pronounced coenzyme Q10 deficiency is a clear indication of the importance of taking Q10 during treatment (and prevention!) Of cancer!

There are many studies that confirm the positive disease progression in cancer while taking Co-enzyme Q10, the studies document an increase in lymphocytes (blood cells know) and of immunoglobulin in the blood of cancer patients! A decrease in disease symptoms bishin to tumor regression has also been documented!

The reasons for this different mechanisms are currently being discussed, ranging from construction of the immune system through improved cell transfer and cell communication, which prevents a degeneration (mutation) of the cells.

Bliznakow et al. succeeded in an attempt to laboratory mice impressively the positive properties of Q10 on tumorigenesis and tumor development to prove!

There, the incidence of tumor formation, tumor size and mortality in a group with Q10 and Q10 without were compared.

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Effect of coenzyme Q10 on the development of cancer:
Days after tumor initiation Tumor formation in the control group Tumor formation in the Q10 group
55 85% 25%
69 100% 55%
77 - - - 77%

Effect of coenzyme Q10 on tumor size:
Days after tumor initiation Control group Q10-group
55 250 sq mm 95 sqmm
69 360 sq mm 170 sq mm
77 930 sq mm 580 sq mm

Effect of coenzyme Q10 on the death rate:
Days after tumor initiation Control group Q10-group
55 5% 0%
111 50% 15%
132 100% ?
Although skeptics will argue at this point, we humans are not mice, it is in mice but to functional organisms and the studies give very good reason for optimism even in the genus "man" - especially since studies in humans corroborate the positive effect:

So could Lockwood et al. * 12 prove astounding success with coenzyme Q10 at 32 (human) patients whose condition seemed hopeless! 3 of the patients had a much lower life expectancy, which fell below the 18-month study period by far!

All patients were initially 90mg Q10 administered daily, leading to outstanding in 6 patients and after all, led to significant improvements in general health at the other 26 other patients! No deaths were recorded, even the typical for the cancer weight losses were from!

To go to the positive effects continue to the bottom, one patient it was decided the Q10 daily dose should be increased to 390 mg, the result:

Already after one month the tumor was no longer palpable and another month later the Mommographie confirmed a complete tumor regression!

In another patient has the Coenzyme Q10 increased dose to 300mg per day, which resulted in complete tumor disappearance after 3 months?

An elderly patient who already had a mastectomy behind and got another tumor disappeared this after six months of treatment with Co-enzyme Q10!

Another prover had around the scar tissue after breast surgery metastasis. The Q10-treatment has even these metastases completely disappear!

In his report on the Q10 Congress in Boston in 1998 Judy et al mentioned. his remarkable success with 600mg Conezym Q10 a day in the treatment of prostate cancer.

In 10 of 14 patients the PSA level after 360 days Q10 treatment by 73.6% and the size of the prostate santa shrank by 48.4% totally free of side effects! * 13

Prof. Folkers reported from long-term studies in which, inter alia, 10 terminally ill cancer patients participated with extremely poor prognosis. After intensive Coenzyme Q10 therapy no more cancer cells in a patient after 3 years have been detected in another after 9 years and a third after 10 years!

The results are attributable to the stimulation of the antibody IgG and T-lymphocytes, as well as to a possible beneficial effect on cytotoxic T cells! This underscores the importance of Q10-taking during a cancer treatment that should be Wore supported by the ingestion of coenzyme Q10.

Coenzyme Q10 protects against the consequences of the operations of tumors
As is known, the physical stress of an operation for increased formation of damaging free radicals. Furthermore, the immune system is strongly suppressed during surgery!

In both cases, coenzyme Q10 can intervene to provide support, namely as an antioxidant and immune system modulator! To support wound healing after surgery, it is recommended that already several days before the operation to OPC and Vitamin C to access (see menu item "OPC" and "vitamin C")

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Coenzyme Q10 to protect against side effects of chemotherapy
The promising studies that substantiate the effectiveness of co-enzyme Q10, speak in the light of the fact that Q10 has shown no side effects even at high doses in numerous studies clearly for the supplementation of Q10 in cancer!

Is treated with chemotherapy, this joins yet another positive feature of coenzyme Q10, namely the protection against side effects of chemotherapy!

How Iarussi et al. could provide in his study of 20 children with non-Hodgkin's lymphoma and lymphoblastic leukemia impressive evidence, the Q10 group remained (10 children, which 240mg ubiquinone was administered Q10) spared the cardiotoxic side effects of the chemotherapeutic agent antracycline! * 14

In animal studies (rats), Valls et al could. demonstrate a protective effect of coenzyme Q10 in front of the typical damage of the cytostatic drug adriamycin, which he attributes to the trapping of free radicals in the mitochondrial membrane by Q10! * 15

Co-enzyme Q10 as protection during radiotherapy and hyperthermia
It is no secret that radiation can cause cancer in itself, paradoxically, due to the increased formation of free radicals, which can lead to cell mutation. Also hyperthermia carries this risk as a side effect!

Here Q10 can intervene preventively as a valuable antioxidant!

It turns in view of the high positive potential at not given side effects not even the question of whether you should take preventive for the prevention of cancer and other diseases Q10 in cancer or.

Summary of the effect of Q10 in cancer:

Q10 improves the disrupted in cancer cell-to-cell communication
Q10 strengthens the persons struggling against cancer, immune system
Q10 neutralizes free radicals, which are also considered a carcinogen
Q10 enhances the positive effects of conventional cancer treatments
Q10 reduces the bad side effects of chemotherapy, radiation & Co

As might be expected the HIV virus leads to a low coenzyme Q10 levels in the body!

Differentiated into three groups, the coenzyme Q10 levels are wiefolgt:

Co-enzyme Q10 levels in the bodies of HIV-infected
Group 1 HIV-Infected Q10 levels as in healthy
Group 2 HIV-infected persons in the preliminary stage to the onset of AIDS Significantly lower Q10 levels
Group 3 AIDS patients Lowest Q10 levels
It has been observed that even patients in group 1 in the course of the transition to group 2 decreased Q10 levels. While initially attributed this to the depression, brought another observation the turn:

During the transition of the group 2 to group 3 significantly lower Q10 levels were still observed!

To go this Phänomone on the track, they decided to start a pilot study!

Under the direction of PH: Langsjoen and K. Folkers study was conducted in the four years found that patients of Group 2 (HIV-infected) are remained free of infection and not to the group 3 changed (AIDS)! *

oenzyme Q10 is also known under the names ubiquinone-10 or simply Q10 known. Ubiquinone roughly translated means "present everywhere". The name suggests: Coenzyme Q10 is present in every cell! The reason: it is an essential part of cellular respiration ( oxidative phosphorylation ). Thus the energy metabolism of the cell is not possible without coenzyme Q10.

Q10 has structural similarities to vitamin E , and vitamin K.

It occurs in everyday life, especially in relation to food supplements and cosmetic creams. Q10 is a very effective antioxidant and helps protect against free radicals. So it can get skin cells healthy and fresh, but protects and supports the male sperm formation.

It is particularly important in the heart muscle, but also in the lungs, liver and kidneys from very concentrated.

Ideally, the body of a healthy person produces enough Coenzyme Q10 itself. When drug intake, stress, obesity, diseases, poor nutrition, or disturbances in the nutritional recovery there may be a shortage.

The additional intake of coenzyme Q10 has in several studies to

a strengthening of the heart and circulation

the improvement of male sperm health

improved regulation of blood pressure

Improving cholesterol and blood lipid levels


Coenzyme Q10 and aging
q10 heart healthCoenzyme Q10 is to make as a powerful natural antioxidant able to neutralize free radicals. It is therefore conceivable, but not proven, that allows a delay in the aging process.

Background of the considerations is that the coenzyme Q10 content especially in the heart muscle, but also in lungs and kidneys, aged continuously decreases. About 70 years have only 40% of the content of Q10 in the heart muscle compared to a young man.

Indications for the use of coenzyme Q10
Coenzyme Q10 functions often used for anti-aging. Q10 is also associated with a reduction of blood pressure and the prevention of cardiovascular diseases by strengthening the heart.

Also for athletes has Coenzyme Q10 a special significance because it protects against free radicals, which are formed reinforced during intense training. Studies have shown that Q10 can improve performance. The additional supply of Q10 is effective in improving endurance and performance by 11% to 30% in athletes.

Strengthening of the heart and circulation
vessels vitamin D circuitAn important area of application for the use of ubiquinone-10 is the fight against heart disease. 's heart needs as much power as no other organ. In Europe, cardiovascular diseases are the most common cause of death. A weakened heart is often associated with a lack of the presence of coenzyme Q10, as it is important for energy production of the mitochondria, and thus affect the cardiac performance critical.

In the past, the overall improvement in angina pectoris, coronary heart disease and heart failure could repeatedly by Q10 in large-scale studies 1 are detected.

The use of coenzyme Q10 for the treatment of myocardial infarction and cardiac rhythm disorders showed good results and could relieve the symptoms and to prevent possible complications of the additional supply of 50-120 mg per day.

A study from Italy has an increased heart capacity by 22% by coenzyme Q10 detected together with pine bark extract ( the study summarized here ).

Generally it is recommended to age to ensure a daily intake of at least 30 mg of Q10 in order to maintain the performance of the body as long as possible.

Increase peak load
In a study of elite athletes, which was published in 2013, it has been demonstrated that the ingestion of 20 mg of Coenzyme Q10 per day may improve the performance peaks at 11% and the total Traininsleistung improved ( more here ). 2

Coenzyme Q10 for healthy blood vessels
Besides the use of coenzyme Q10 in the prevention and treatment of heart disease, it is also used for disorders of the central nervous system such as Parkinson's or Alzheimer's.

These have a close connection to the damaging effects of free radicals, which cause oxidative stress and permanently destroy nerve cells 3 4 .

Coenzyme Q10 in diabetes mellitus
regulate blood sugar levelsUbiquinone-10 also in case of diabetes is great potential for improvement, because it stop the consequential damages, or may reduce 5 . By persistently raised blood sugar levels kidneys, nerves and blood vessels are permanently attacked and can cause heart attacks, strokes, amputations and even blindness.

Coenzyme Q10 stabilizes cell membranes and leads to increased energy throughput, which protects the insulin-producing cells of the pancreas and can lead to a higher power. Q10 also lowers blood pressure and blood sugar levels.

Cancer patients have too low Q10 levels on
Another important role of coenzyme Q10 is in the prevention and therapy of malignant cancers. About 20% of cancer patients have a significantly low levels of ubiquinone-10 in serum, which is why a strong suspicion that a too low intake of Q10 promotes the development of malignant tumors. Especially breast and lung cancer usually go with a significant coenzyme Q10 deficiency is associated.

Fertility of men: Q10 is important
Male fertility Q10The fertility of men decreases at a rate of about 2% per year, or approximately 36% in two decades. The diet and oxidative stress play a central role in the causes of an increasing number of infertile men.

Coenzyme Q10 is also in the male sperm in the center of energy metabolism. In studies it has been found that the intake of coenzyme Q10 can significantly improve the forward motility of spermatozoa in subfertile men. 6

Dosage of coenzyme Q10
Coenzyme Q10 is produced partly by the body itself. Especially organs such as the heart, the lungs or the liver have an increased energy demand and are therefore dependent on a steady supply of ATP, which is synthesized to 95% with the help of ubiquinone-10.

Leading scientists recommend a daily intake of 30-200 mg daily 7 . This quantity can be reached with little natural foods, because you sure about 1.6 kg sardines or example, 3 kg of beef would have to eat in a day.

Side effects are not expected at much higher doses. In one study, 3,000 mg of coenzyme Q10 were taken per day for 8 months in another study, 1,200 mg daily for 18 months. In both cases, there were no significant side effects. 8

Statistically, is only 25% of the population a sufficient saturation with Q10 before, which is almost exclusively are children and young people, because with them the body's production is even higher.

Manufacture and side effects
Q10 to produce larger quantities industrially, the fermentation of bacteria, the fermentation of yeast and the chemical synthesis can be used exclusively in the meantime. In the yeast fermentation in the result is a product identical to the natural occurrence coenzyme Q10, which has been studied in several safety studies. It was shown that a daily intake of up to 900 mg of the generated in this way ubiquinone-10 completely safe and well-tolerated is 9 .

There are some high-quality studies conducted that demonstrate the positive impact of coenzyme Q10 on the heart and on the sperm production of the man. In the USA and Asia, it has long become a standard, Q10 in support of cardiovascular and in the fight against arteriosclerosis use.

Article Wiki Closed - COENZYME Q-10: Benefits, Side Effects, Uses, Dosage, Warnings?
asked Aug 13, 2014 by Lancomega Level (10,245 points)