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Evening Primrose Oil: Benefits, Side Effects, Uses, Dosage, Warnings?

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EVENING PRIMROSE OIL: Benefits, Side Effects, Uses, Dosage, Warnings?

How effective are selected medication from the pharmacy? Is there convincing data on the efficacy of herbal medicines? When to natural remedies work? As it is with the effects of vitamins and minerals? The following contributions Rate medicines and natural remedies on the basis of current scientific publications.

Evening primrose oil for the treatment of neurodermatitis - effective or ineffective?

Evening primrose oil for the treatment of atopic dermatitis

Evening primrose oil reduces itching and reddening of the skin in atopic dermatitis?

Background
Evening primrose oil supplements are recommended as drugs and dietary supplements for supportive treatment in atopic dermatitis / eczema.

evening primrose oil (Oenotherae oleum) is extracted from the seeds of evening primrose species, especially the commons evening primrose (Oenothera biennis L.), won. Evening primrose oil contains approximately 8-14% gamma-linolenic acid and 65 to 80% linoleic acid.

As medicaments evening primrose oil is approved for the treatment of atopic dermatitis (eczema), especially for the treatment of accompanying pruritus.

As dosage for the treatment of eczema taking up is to 6 g of evening primrose oil per day is recommended (trade name: Epogam® soft capsules, Gammacur® capsules, Neobonsen® capsules, Efamol® capsules).

Experience reportedly are the typical symptoms of eczema such as itching, scaling, skin inflammation or redness positively influenced by treatment with evening primrose oil.

Mechanism of Action
As the essential active ingredient of the evening primrose oil, the gamma-linolenic acid (Gamolensäure) is considered.

the tri-unsaturated gamma-linolenic acid synthesized in the body from linoleic acid. Particularly rich in gamma-linolenic acid are borage oil (21%), black currant oil (14-19%) and evening primrose oil (9%).

Though gamma-linolenic acid can be formed from the abundant in the body linoleic acid itself, is a deficiency in the skin possible. This is explained by the fact that the formation of sufficient amounts of gamma-linolenic acid, the enzyme delta-6-desaturase is necessary. The activity of this enzyme may be genetically determined, be reduced due to metabolic disorders (diabetes) or as a result of the normal aging process.

From a variety of studies have shown that gamma-linolenic acid-containing oils one after internal use in patients with eczematous skin lesions renew damaged skin barrier, normalize the increased transepidermal water loss and improve skin smoothness.

Studies on the efficacy of evening primrose oil
In a first meta-analysis of clinical data from the year 2006 a total of 26 trials involving 1207 patients were included in the indication of atopic dermatitis. The analysis concludes that the treatment with evening primrose oil after 4 to 8 weeks duration can have a positive effect on itching, crusting, edema and redness (erythema) (1). It was noted, however, that simultaneous cortisone therapy might reduce the effectiveness of evening primrose oil.

For a contrary assessment, the review article of an American working group comes from the year 2008: According to the previously published study results on the efficacy of evening primrose oil in the treatment of atopic dermatitis were insufficient to . too can express a treatment recommendation (2)

Another study from 2009 essentially confirmed this result: According to the authors, can be found in the studies conducted so far there is insufficient evidence for a clinically relevant improvement in the eczema under oral therapy with evening primrose oil ( 3).

Chance can be found in the literature positive study results on the use of evening primrose oil in atopic dermatitis. These are usually based on small studies.

As an example, an Indian study of 50 patients with clinically confirmed is called atopic dermatitis (4). Over a period of 5 months of 25 patients received either 500 mg of evening primrose oil or identical-looking capsules containing sunflower oil received. Before and after the treatment, the efficacy was evaluated on the basis of the extent and intensity of itch, and skin dryness. Result: At the end of the fifth month showed 24 (96%) of patients in the evening primrose oil group and 8 (32%) of patients in the comparison group, a clinically relevant improvement. The difference from the control group was statistically significant.

More reviews on the effectiveness of evening primrose oil
The well-known for their critical comments drug-telegram ordered gamma-linolenic acid in evening primrose oil as a "controversial therapy principle" one whose effect is "can also be achieved by Hautexterna". The benefits of essential fatty acids such as gamma-linolenic acid / Gamolensäure (eg in evening primrose oil) is unclear, according to drug-telegram or not used (Information as of: 2003 (5)).

In a recently published Cochrane meta-analysis of oral therapy of atopic was dermatitis / eczema rated with evening primrose oil again (6). In this analysis, the results were taken into account by a total of 19 clinical studies. The main result was that the treatment with evening primrose oil compared to placebo did not significantly improve the symptoms of eczema. In the evaluation of symptoms, the assessments of the patient and the treating physicians were included. The authors concluded accordingly that evening primrose oil is no effective treatment of eczema or atopic dermatitis representing (6).

Compatibility
While taking evening primrose oil indigestion, nausea and headache have been reported as side effects. In the treatment with evening primrose oil may cause the occurrence of previously recognized seizures. An anticoagulant effect (inhibition of blood clotting) and inhibition of platelet aggregation can not be excluded (7).

Conclusion
In the studies published to date, the efficacy of evening primrose oil for the treatment of symptoms of atopic eczema / atopic dermatitis could not be properly substantiated. Although positive effects of evening primrose oil are documented on selected symptoms of this skin disease in smaller studies, this is not sufficient for a general treatment recommendation.

What is evening primrose oil?

"An answer to What is evening primrose oil "is: A versatile remedy, cytoprotective and anti-inflammatory, suitable for internal and external use.

Originally from America, the evening primrose was brought to Europe about 400 years ago and spread rapidly due to its low requirements for location of. First, it was a popular ornamental plant, but was soon discovered that evening primrose have high healing power and are very versatile. But what is evening primrose oil exactly? It is obtained by pressing and extraction of the tiny seeds of the plant and contains valuable polyunsaturated fatty acids, minerals and amino acids also include natural fragrances and dyes.

What is so healthy in evening primrose oil?
The essential fatty acids contained can not be manufactured by the body and must be supplied daily. Evening primrose oil is composed of approximately 80% of gamma-linolenic and linoleic acids, both essential for establishment and maintenance of cell membranes and to break down fat cells. They also receive hormonal balance, support the immune system and its functions and help in the regulation of cholesterol.

What is so special about evening primrose oil?
Evening primrose oil fights inflammation in the body, on the one hand by altering their chemical messengers and the other strengthens the body's immune system. Applied externally, it moisturizes, strengthens the protective barrier of your skin and provides suppleness and elasticity.
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What is evening primrose oil for your skin?
If you suffer from chronic and inflammatory skin diseases such as psoriasis and / or eczema, evening primrose oil is just right for you as it relieves itching, scaling and inflammation and regenerates the skin cells. At the same time internally, it increases the healing effect in addition.

But evening primrose oil can do even more: It helps in chronic joint and spinal inflammation (rheumatoid arthritis, ankylosing spondylitis), the phytohormones contained relieve the symptoms of PMS and help you gently and carefully with menopausal symptoms .

See also:
What are plant hormones?
Tip: The health benefits are only available with top quality, cold-pressed evening primrose oil from organic cultivation!

Conclusion: What is evening primrose oil? A universal natural remedy that not only the aging process of your skin is staying, but also your body helps fight inflammation and maintain hormonal balance.

Article Wiki Closed - EVENING PRIMROSE OIL: Benefits, Side Effects, Uses, Dosage, Warnings?
asked Aug 13, 2014 by Lancomega Level (10,245 points)
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