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Saw Palmetto: Benefits, Side Effects, Uses, Dosage, Warnings?

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SAW PALMETTO: Benefits, Side Effects, Uses, Dosage, Warnings?

Common Names: Sabal (berries), saw palmetto.
Botanical Names: Serenoa repens, Sabal serrulata , family aracacées.
English names: Saw palmetto, American dwarf palm, cabbage palm .

Part used: Berries.
Habitat and origin: Native to southeastern United States, especially Florida, this small palm tree with larger specimens rarely exceed 3 meters clearly prefers dry, sandy soils. These are the berries, about the size and shape of the olive, which are popular for their therapeutic qualities.

Indications
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Effective
Treat benign prostatic hyperplasia.
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Likely effectiveness
Palmetto combined with nettle root - Relieve urination problems related to benign prostatic hyperplasia (phases I and II).
Uncertain effectiveness
Treat chronic prostatitis (inflammation of the prostate).
Recognized use
Relieve urinary symptoms associated with benign prostatic hyperplasia.
Dosage of saw palmetto
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Benign prostatic hyperplasia

Standardized extract (10: 1 to 14: 1, or from 85% to 95% fatty acids and sterols). Take 160 mg, 2 times daily. It is with this type of extracts that clinical trials were conducted.
Standardized extract (4: 1, 25% fatty acids and sterols) . Take 500 mg, 2 times daily.
Fluid extract (1: 1 g / ml). Take 1 ml to 2 ml, 2 times daily.
Fluid extract (1: 2, g / ml). Take 2 ml to 4 ml, 2 times daily.
Standardized extract combined: take a daily supplement containing 240 mg of nettle extract and 320 mg of saw palmetto extract.
Notes
- The effect of extracts of saw palmetto may take 4 to 6 weeks to show up .
- If symptoms of benign prostatic hyperplasia, consult a doctor before self-medicating.

History palmetto
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PalmettoIn Seminole Native Americans who once inhabited Florida, berries of saw palmetto were used as food. They are also used to treat various disorders of the urinary tract in men, and treat breast problems in women. The Europeans, who found that the berries of the saw palmetto had an unpleasant taste of soap, have maintained that the medicinal uses. Doctors at the American eclectic school used mostly to treat symptoms related to benign prostatic hyperplasia (BPH). Saw palmetto was first included in the official list of drugs in the United States until 1950, when he fell into oblivion due to adverse physicians of the time maintained towards traditional medicines prejudices.

However, the plant has remained popular in Europe, and they are French doctors who developed in the 1960s, the type of lipophilic extract (extracted with oils) that most often used today . In Germany, Austria and Italy in particular, this excerpt from Palmetto (Permixon®) is widely used as first-line treatment of benign prostatic hyperplasia.

During the 1990s, the plant has re-entered America in the circuit of food stores. The saw palmetto is often combined with other herbs to combat benign prostatic hypertrophy, including nettle, African cherry and pumpkin seeds.

It was suggested that other therapeutic uses for saw palmetto, from the treatment of male hair loss to increase breast size in women, but for now, the clinical evidence missing.

Research on Saw Palmetto
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Effective Benign prostatic hyperplasia (BPH). Several meta-analyzes and syntheses concluded that saw palmetto was more effective than placebo in reducing symptoms cleanly of benign prostatic hyperplasia 1-7 . One of these meta-analyzes published in 2004, focused on the Permixon®, an extract of saw palmetto marketed in Europe, that has undergone the majority of studies 4 . However, at least another extract yielded conclusive results during a recent test conducted in China (Prostataplex®) 8 .

The researchers also compared the effect of Permixon® than synthetic prescription drugs: Finasteride (Proscar, for example) and tamsulosin (Flomax®), for example) during two trials involving over 1900 subjects in all, the plant was as effective 9,10 these drugs while having fewer side effects on sexual function. In terms of efficiency, an observational study conducted in 6 European countries still give the advantage to Drugs in Palmetto 11 . However, according to a study conducted in Spain, Permixon equally effective, costs less than 211 euros is tamusoline year, rather than 346 euros 12 .

In 2006, a double-blind study of high methodological quality has cast doubt on the effectiveness of saw palmetto because it was inconclusive. Conducted in the United States, it focused on 225 men with benign prostatic hyperplasia with moderate to severe and lasted for 1 year 13 . Following this test, some authors concluded that saw palmetto had not proven 14,15 . Only one test can however cancel many positive results obtained previously. Moreover, doubts have been raised on several points of the study: active ingredient content of the supplement used (see our new Effective or not, saw palmetto? about it); classification system symptoms and stage of disease too advanced for the subjects to benefit from the effects of saw palmetto in the dosage employed (320 mg daily) 16.17 .

Likely effectiveness Benign prostatic hyperplasia (combination palm and dwarf nettle). This mixture is often used in Europe, as nettle also has beneficial effects in cases of urinary problems. In 1995, a study su (without placebo), conducted among 2080 subjects treated with an extract of these two plants, has been successfully completed 18 . The results of two double-blind studies of 24 weeks, as well as a free follow-up placebo for 48 weeks 21 have confirmed the efficacy of the combination of these two plants 19.20 . The researchers used standardized extracts providing 320 mg of saw palmetto and nettle 240mg per day (Prostagutt Forte, also known as PRO 160 / 120®).

In addition, this product was as effective as conventional drugs finasteride and tamulosine during two trials 22,23 a period of 1 year. This natural treatment of benign prostatic hyperplasia is increasingly accepted by the medical community, especially in Europe 24 .

Recognized use The Commission E and the World Health Organization recognizes the use of saw palmetto for treating urinary disorders that accompany benign prostate mild to moderate (stages I and II).

It is not known precisely the mechanism of action of saw palmetto . However, it is generally believed that, like conventional drugs, the plant would prevent or reduce the conversion of testosterone to dihydrotestosterone 25.26 , a substance that would intervene in the development of benign prostatic hyperplasia . It would also have an anti-inflammatory effect and influence beneficially the estrogen / testosterone ratio 27 . The results of a study on tissue from patients treated with saw palmetto indicate that it would promote natural death (apoptosis) in prostate cells, which would prevent or slow its hypertrophy 28 .

Uncertain effectiveness Prostatitis. This chronic prostate inflammation and benign prostatic hyperplasia have common symptoms. We therefore examined whether saw palmetto might be useful to treat prostatitis, but the results have been contradictory 29-31 .

Miscellaneous. An epidemiological study published in 2006 did not establish a link between the consumption of supplements palmetto and a reduced risk of prostate cancer 33 . However, some researchers continue to examine the potential protective effect of saw palmetto against cancer. The data remain preliminary at this time 34-36 .

Precautions
Watch out
Although the effectiveness of saw palmetto is established for the treatment of symptoms of benign prostatic hypertrophy, it is advisable not to stick to self-diagnosis and consult a doctor before self-medicating.
Cons-indications
While saw palmetto is not used by women, note that because of the theoretical possibility that the saw palmetto extract has estrogenic or anti-androgenic activity 27 , it is against-indicated in pregnancy.
Adverse effects
Rare cases of gastrointestinal benign 37 . It is suggested to take the saw palmetto extracts eating to avoid these possible side effects.
The usually recommended doses, the use of saw palmetto is safe , according to the author of a detailed analysis of the safety of the plant during a 1-year study 38 .
According to a synthesis having scrutinized 3 trials, taking saw palmetto (Permixon®) does not have a negative effect on male sexual function , unlike conventional drugs (finasteride and tamsulosin hydrochloride) that cause problems mainly ejaculation 39 . However, another case of synthesis refers to diminished libido 37 .
Interactions
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With plants or supplements
None known. However, two anecdotal cases of increased bleeding time 40 brain hemorrhage and 41 were reported: the palmetto should be used with caution in people taking plants with anticoagulant and antiplatelet properties (garlic, ginkgo biloba, ginseng) .
With drugs
Both anecdotal cases of increased bleeding time 40 and cerebral hemorrhage 41 have been reported. The saw palmetto should be used with caution in patients taking anticoagulants and antiplatelet drugs.
A case of skin sensitization to a cream containing saw palmetto has been reported as a result of sensitization to minoxidil, an agent used to combat male pattern alopecia 42 .
On the shelves
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In 2004, researchers analyzed 14 extracts of saw palmetto sold in the United States. The content of free fatty acids (the main active ingredient suspected) ranged from 40.7% to 80.7%. The content of the 14 products as varied greatly in the case of four other tested compounds (methyl and ethyl esters, long chain esters, glycerides fraction unsaponified) 43 .

In 2006 and 2008, the independent laboratory ConsumerLab.com analyzed 20 supplements of extracts lipophilic (oil extracts) of saw palmetto : The content of 3 of them did not conform to their label 44 .

March 22, 2002 - The dwarf sabal palm or ( Serenoa repens ) is again talking about him in a study published in the journal Urology that assessed its effect on men with urinary retention (inability to urination), one of major cause is benign prostatic hyperplasia. 1

The researchers administered two tablets of saw palmetto daily for six months to a group of men complaining of symptoms of urinary retention and a placebo to another group. Urinary symptoms, sexual function, quality of life and urinary flow were compared in both groups after the first, second, fourth and sixth months of treatment. To estimate the urinary symptoms, the questionnaire International Prostate Symptom Score (IPSS) 2 was used. A second questionnaire focused on sexual function and quality of life. Urinary output was also measured.

At the end of the study, men who received treatment with saw palmetto tablets experienced a decrease in symptoms of urinary retention (4.4 points compared to 2.2 for the placebo group). The quality of life of the group "under palmetto" increased slightly, but the results did not seem significant enough to draw conclusions. No changes were observed for sexual function and urinary flow.

The results related to urinary retention confirm those of previous studies and researchers encouraged doctors to inform their patients of the potential benefits of saw palmetto although its mode of action is unknown at this time. They also reiterated that preparations on the market change from one brand to another, implying that the dosage may vary.

Product Description
The Indians of the Florida peninsula have traditionally used the fruits of Palmetto for disorders of the urinary tract in men. American doctors then adopted this plant in the treatment of benign prostatic hyperplasia. This plant is traditionally recognized as being able to improve urinary comfort viellissants men.

Additional Information
Terms of use The usual dose is 4 capsules daily, away from meals, two samples distributed throughout the day.
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Quality Indicators No flavor, no coloring, no preservatives
Warning The treatment of benign prostatic hyperplasia should be done under medical supervision.
Composition
- Fruit powder Saw Palmetto (Serenoa repens) 250 mg
Adjuvants Colloidal silica 7 mg Magnesium stearate 5 mg
Galenic form and Packaging Capsule containing 250 mg of saw palmetto powder box of 120 capsules
Nota bene Dietary supplements should be used as part of a healthy lifestyle. They do not in any way a varied and balanced diet. Do not exceed the recommended daily dose Keep out of reach of children

Article Wiki Closed - SAW PALMETTO: Benefits, Side Effects, Uses, Dosage, Warnings?
asked Aug 13, 2014 by Lancomega Level (10,245 points)
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