ACETYL-L-CARNITINE: Benefits, Side Effects, Uses, Dosage, Warnings?
Acetyl-L-carnitine: For brain and reproductive
Acetyl-L-carnitine (ALC) occurs naturally in the human body. Is particularly high content in the heart, in the muscle and testis. ALC can cross the blood-brain barrier and is acetylcholine involved in the formation of acetyl groups for the synthesis of the neurotransmitter. It therefore plays an important role in the energy metabolism of the brain and nerve cells. Acetyl-L-carnitine is important for a good memory performance.
is important for the formation of acetylcholine in the brain
plays a role in the parasympathetic nervous system
is important for sperm motility
may have significance for male fertility and fertility
n important cause of aging is a reduction of the energy-generating components of the cell, which leads to a reduced cellular metabolism and accumulation of cellular waste products (1-7). L-carnitine helps maintain cellular energy metabolism within the cell by supporting the transport of fatty acids from the cytosol into the mitochondria, where the fats are oxidized to produce the cellular energy adenosine triphosphate / ATP (8-13).
Acetyl-L-carnitine is the acetylated amino acid ester of L-carnitine. Acetyl-L-carnitine is an endogenous mitochondrial membrane component that helps in maintaining mitochondrial bioenergetics and increased oxidative stress caused by aging decreased (14). Acetyl-L-carnitine and L-carnitine are very well absorbed by the bloodstream. Both act effectively when passing locks long chain fatty acids across the membrane into the mitochondria where they can be burned for energy and effectively utilized by the cell (15-18). Acetyl-L-carnitine also protects against oxidative damages (5.19 to 21). The amyloid-beta peptide is a major component of plaques, of the peptide, it is believed that it contributes to the aging process. Acetyl-L-carnitine unfolds protective effects against such neurotoxicity and oxidative stress (14).
In addition to supporting the cellular energy metabolism promotes acetyl-L-carnitine arginate, a patented form of carnitine, an optimal brain health.
1 vegetarian capsule Acetyl-L-Carnitine-Arginate contains: Acetyl-L-Carnitine Hydrochloride 300 mg ArginoCarn acetyl-L-carnitine arginate dihydrochloride 320 mg Other ingredients: veg. Cellulose (capsule), rice flour, ascorbyl palmitate. Life Extension recommends 1 capsule Acetyl-L-Carnitine-Arginate 3 times per day. Acetyl-L-Carnitine-arginate should be taken on an empty stomach. The capsules can at once or throughout the day are taken. advice: Keep out of reach of children * Do not exceed recommended dosage. * When bad reaction to the product, stop using the product immediately. * Call, ask your doctor if you want to use dietary supplements and are undergoing treatment for a medical condition or if you are pregnant or breastfeeding.
Acetyl-L-carnitine is the biologically active form of the amino acid L-carnitine . It is water soluble and acts in particular on the central nervous system, where it has a positive effect on attention, concentration, mood and cognitive memory after administration. End of the 90s it became apparent that acetyl-L-carnitine is beneficial for the neurotransmitters and brain cells. Due to its influence on the function of the central nervous system, the researchers with the effects of supplementation with acetyl-L-carnitine explained in the case of Alzheimer's. The researchers are of the opinion that 1.5 g to 3 g of acetyl-L-carnitine may prove daily as necessary for the first stages of the disease. acetyl-L-carnitine could in the treatment of age-related disorders, such as dementia, be used. Here, the neuroprotective activity can be improved by this supplement. The researchers have also shown that acetyl-L-carnitine prevents the process of degeneration of nerve cells. It mainly protects against cerebral ischemia.
This property suggests that acetyl-L-carnitine could be used for protection against thrombosis or brain embolism. In diabetics could acetyl-L-carnitine reduce the process of Linsenglykation. This is a disorder that causes cataracts. In the sports world is Acetyl-L-carnitine known as "fat burners" in particular for its natural effect. It is able to preserve the mitochondrial function and restore. It contributes to the conversion of fat stores into energy. More specifically, it acts on the muscle fiber by it for better combustion of fats, which is beneficial for endurance athletes, provides. acetyl-L-carnitine also prevents the occurrence of convulsions before, which are caused by the lactic acid. Over 700 scientific studies confirm the efficacy of acetyl-L-carnitine improve endurance and athletic performance. acetyl-L-carnitine is also critical for cellular regeneration of the heart, the liver and the peripheral nervous system. This makes it deserve a versatile anti-aging product that attention.
Miraculous effects in the mitochondria:
Confirms successful treatment of Nicuta regeneration therapy
In a special combination of two simple food additives appear to have an extremely rejuvenating effect on the cells. Biomedical highly prestigious University of California have now demonstrated this effect unambiguously. In animal experiments, the natural aging process was thus already halted and even reversed. The research findings from the United States impressively confirm the findings of the German-Romanian physician Dr. Dr. Then Nicuta. The well-known regeneration researchers had discovered in the late nineties, the effect of these substances and made part of its highly effective medical therapy regeneration. Although many formerly old sick and frail patients the so-called Nicuta therapy owe their recovered health and an often astonishing fitness, the complex mechanism of action of the treatment has so far only be explained theoretically. The new American research results have hypotheses Dr. Nicutas now but impressively bestätigt.Berkeley / USA. The results are stunning. Under the electron microscope is perfectly apparent that the cells have regenerated treated animals and again correspond to the structure of young cells - a phenomenon that even the scientists responsible for the research initially made speechless by the renowned cell biologist Prof. Dr. Bruce N. Ames. "Translated to humans," said Dr. Tory M. Hagen, one involved in the research biomedical, would make a 75 to 80-year-old man, a middle-aged person, the effect of the substances. "What happened in the cells?
Within standardized test series on the bioavailability of various substances, cell biologists had fed the active acetyl-L-carnitine and alpha-lipoic acid in rats at the famous University of California among others. Both substances occur in human body cells naturally and have long been commercially available. While the active ingredients of each exerted no visible effect on the animals, however, showed a combination of more or less randomly found both substances unbelievable results. "The old rats were dancing the Macarena", described Prof. Dr. Ames the surprising effect of the drug combination used by him. And indeed, the discovery of the examined research studies show unequivocally that must have really played a force explosion in the old animals
The really at the end of their life cycle standing, age-damaged rats behaved when they were fed with acetyl-L-carnitine and aipha-lipoic acid, already after one month significantly more agile in the progress of the trials they finally responded even again as young and vigorous fellows, both in memory-like performance tests showed the results of young animals, laid promptly again the strong pairing behavior of young animals on the day and lived much longer. The running against the experimental groups control groups did not show this effect, however, and died within the expected time periods.
Interested readers can request under the title "Dietary supplements make old rats youthful, june help rejuvenate aging humans, accor ding to UCBerkeley study" published research results and the aforementioned studies at the University of California, Berkeley / USA. Publication number: 510-643-6998 (Contact: Robert Sanders). The work of Ames et al. were also published in the February issue of the Proceedings of the National Academy of Sciences USA (PNAS). The PNAS founded in 1914, is the official organ of its kind probably greatest union of the United States (see Box: Original Sources, p 7).
Started the first clinical trials in the United States
Professor Ames and his teammates have come up immediately patented the special combination of the two substances and do the treatment as soon as possible also perform with people. The American pharmaceutical company Juvenon has already adopted the exploitation of the patent and started the first clinical test. But as always, when a new drug is found: Until the mandatory clinical trials in all phases performed and evaluated or to a regulatory drug approval of the new drug takes place, be sure it takes years.
GERO-funders must to by many people surely awaited approval of the new Juvenon
Drug but not to wait. By the late nineties had known of Regenerative Medicine Dr. med. Dr. phil. Then Nicuta recognized the rejuvenating effects of acetyl-L-carnitine and alpha-lipoic acid and developed its own combination mixture of these two substances. Its functioning on the basis of the drug procaine regeneration treatment is therefore supplemented for about two years by oral administration of acetyl-L-carnitine and alpha-lipoic acid. Indeed, the successes they have achieved more than impressive and confirm the findings of the American cell biologist Prof. Dr. Ames in every respect. For Nicuta patients the Fountain of eternal youth has come true.
In Germany already implemented
The profiled German cell biologist and GERO-scientist Jürgen Mathias has been compared in the context of the research for this report, the American research with the treatment foundations of so-called NicutaTherapie. He and many of his scientific colleagues are now confident that we have the biomedical explanation for the "miracle treatment" found that can make old sick and frail patients again strong, fit and full of life participating people. The author of GERO-book The formulas of eternal youth stated: "Dr. Nicutas considerations were spot on, even if he could not prove the reason for his treatment successes.. The key for a comprehensive rejuvenation of the organism is clearly in the mitochondria, the likely now be biologically and medically finally clear. "
Jürgen Mathias, who knows quite a few Nicuta patients and their individual medical histories well, was initially almost stunned by the outcomes that will be achieved with this method now: The statements of the animal studies of Prof. Dr. Ames meet 'to. Even 80 to 90-year-old patients get back the condition. The appearance improved significantly. "GERO The scientist is pleased to have Dr. Dan Nicuta, the 1999 unfortunately died much too early founder of this unique regeneration therapy, yet well known personally.
A gifted physician
Dr. Dan Nicuta was a student of the world-famous physician and cell researcher Prof. Dr. Ana Aslan of Bucharest and one of the founders of the legendary German Aslan Society in 1986, he became medical director of the Medical Institute operated by the company in Sauerland Olsberg. Until zurAufgabe this Institute by the German Aslan Society in 1994 celebrated Dr. Nicuta here spectacular successes. Numerous celebrities were constant patient of the gifted physician, including, for example, Heinz Riihmann, Günter Strack, Inge Meysel, Willy Millowitsch, Alfred Biolek, Omar Sharif, Zsa Zsa Gabor and many other more or less prominent contemporaries from around the world.
Although Dr. Nicuta the Aslan'schen treatment methods sovereign dominated like no other, he was soon no longer really pleased with the results of this procaine therapy and research from the mid-nineties intense new treatment regimens and drugs, the effect of the procaine could assist Aslan therapy. In this case, it was mainly his wife Vesna, an experienced and also with the Aslan'schen therapy well familiar Specialist, to the side. This cooperation, it is thanks to them that the original treatment
method could always be further improved and has to do with the traditional procaine therapy according to Prof. Aslan today only relatively little. The two doctors inserted the procaine treatment, among other sophisticated Vitaminmixturen, primarily vitamin C, E and certain vitamins of the B group, hormone therapy, applications of orthomolecular medicine, neural therapy and other medical procedures added.
Effective in the mitochondria
The therapy with Gero H3 Aslan, developed by Professor Aslan around 1950 original product (freely available as pills and Injektionsiösung in pharmacies, Importer: German Chefaro Pharma GmbH, 45725 Waltrop), is aimed at regeneration of mitochondria. Prof. Dr. Dr. Aslan himself, and numerous other researchers have this effect often studied and described. Then ingredients act of procaine contained in Gero H3 Aslan on the "fuel budget" of the mitochondria and increase the production of ATP (the life energy of the cells) important acetyl-CoA levels. Unfortunately, however, this effect is of relatively short duration. Procaine breaks down in the body within a short time and loses its effect. A really significant re action of Procaintherapie on the acetyl-CoA levels can therefore be achieved only with accompanying substances which stabilize the procaine. Dr. Nicuta knew about these events and searched for these substances.
It is obvious that the doctors Dan and Vesna Nicuta soon experimented in their research with alpha-lipoic acid. The substance is available in different preparations and is described in the medical literature as a cell protectant, which penetrate into the mitochondria and there obviously can scavenge free radicals. And the acetyl L-carnitine acts in the mitochondria. The compound has a stabilizing influence on the energy of the cell organelles and is therefore, inter alia, for the treatment of Alzheimer's disease. And indeed Dr. Nicuta came up with the idea that a combination of both drugs could trigger special effects, in the treatment of patients in Alzheimer's preliminary, the acetyl-L-carnitine tablets had been prescribed by their GPs.
Dr. med. Vesna Nicuta, the internationally successful with his medical knowledge has become ex-Aslan pupil's widow, leads the life of her husband works on today and forwards the known Nicuta Institute in Willingen Hesse. The savvy Specialist in Intensive Care Medicine and General Practitioner can still remember the patient, in which the significant rejuvenating effect of acetyl-L-carnitine and alpha-lipoic acid has been found for the first time. The old lady was suffering from Alzheimer's disease and age-related wear on several diseases. Dr. Vesna Nicuta today: "We suddenly saw almost miraculous bordering regeneration effects after oral alpha-lipoic acid doses Without the basic therapy with acetyl-L-carnitine, these effects were previously undetectable, the patient recovered rapidly, symptoms remained off.. actually been lost for ever believed power came back. "
Dr. Dan Nicuta repeated this success with later he developed a combination of the two substances and made this special ingredient mixture to the part of his famous procaine regeneration therapy. But the cause of the sometimes overwhelming success of the use of Acetyi-L-carnitine in combination with alpha-lipoic acid remained all his life a mystery. The former Aslan scientists assumed that
the substances only increased the effect of the further developed by him Aslan'sehen Procaintherapie.
His successor, Dr. Vesna Nicuta is convinced that the two food additives orally given of her actually add only the procaine effect. That a combination of Acetyi-L-carnitine and alpha-lipoic acid also apparently a
completely independent regeneration effect has experienced regeneration physician has quite surprised. Nevertheless, it is of course happy about the Californian research results and looks through the studies of Prof. Dr. Ames and his scientists of her late husband's medical findings strongly confirmed.
Mitochondrial functions are sustained stimulated.
"We have, even if by default, already recognized as a cause of early onset of aging and numerous related suffering in any case then enigmatic disorders of mitochondrial function," the old physician GERO told and explicitly emphasizes: "We naturally developed from my husband drug combination in the treatment of age-related wear and tear diseases by default., but I am still of the opinion that the significant and immediate onset of stimulation of mitochondrial functions is due in this case to the interlocking effect of all three substances. I mean specifically alpha-lipoic acid, acetyl-L- carnitine and procaine. Perhaps should the Berkeley University to pursue this connection again separately. "
Smashing success: after all, whether with or without procaine-based therapy: What the American cell biologist can show only in animal experimental stage is reached within the Nicuta therapy for several years. Former old sick and frail patients owe this regeneration treatment their health and indeed amazing spiritual and physical fitness. GERO-General Dr. Rolf Müller Cornelius, who was a close friend of Dr. Dan Nicuta expressed, sichkürzlich in a lecture on the future of medicine to the spectacular research from Berkeley and the resulting now made possible confirmation of Nicuta'schen treat- ment hypotheses " The treatment successes achieved my friend Dr. Dan Nicuta with his regeneration therapy, often topped my medical imagination. these to success is his wife continued consistently. I know about 90-year-old patient of hers who actually had no more chance and today again merry sport.